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vulnerable to Alzheimer’s disease pathology than others remain largely unknown. Here we studied molecular properties underlying these distinct regional vulnerabilities by analysing Alzheimer’s disease -typical ...
has been proposed to explain the conformational conversion from physiological protein into misfolded, pathological form, mode of toxicity, propagation from cell ‐to‐ cell and regional spread ...
Abstract The role of neuroinflammation in the pathogenesis of neurodegenerative diseases has become more evident in recent years. Research on the etiology and pathogenesis of sporadic Alzheimer’s ...
PRESENILIN-1 (PS-1) and amyloid precursor protein (APP) have been linked to the pathogenesis of Alzheimer ' s disease . While APP accumulation is well documented in several models of brain injury ...
, † 1,3, † Cookson , Steven S . Gross , Ernest Fraenkel , Karen E. Duff , and Estela Area-Gomez 1 th Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 West 168 ...
Selective neuronal dysfunction and degeneration are defining features of Alzheimer’s disease (AD). While the exact mechanism( s ) contributing to this selective neuronal vulnerability remains ...
and hippocampal region in Alzheimer’s -free 62–85 year old subjects (indicated in red in the arrow illustration above), shows that the dentate gyrus is most vulnerable to aging (although not crossing threshold ...
of the brain most vulnerable to Alzheimer’s disease (AD) and LH is significantly elevated in both the serum and the pyramidal neurons of AD subjects. LH promotes the amyloidogenic processing of the amyloid-β ...
the therapeutic implications they present. Graphical Abstract Open in new tabDownload slide This minireview elaborates on the roles of iron, copper, and zinc in Alzheimer's disease and describes the therapeutic ...
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