Regional brain volume changes following chronic antipsychotic administration are mediated by the dopamine D2 receptor

Regional brain volume changes following chronic antipsychotic administration are mediated by the... BackgroundNeuroanatomical alterations are well established in patients suffering from schizophrenia, however the extent to which these changes are attributable to illness, antipsychotic drugs (APDs), or their interaction is unclear. APDs have been extremely effective for treatment of positive symptoms in major psychotic disorders. Their therapeutic effects are mediated, in part, through blockade of D2-like dopamine (DA) receptors, i.e. the D2, D3 and D4 dopamine receptors. Furthermore, the dependency of neuroanatomical change on DA system function and D2-like receptors has yet to be explored. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroimage Elsevier

Regional brain volume changes following chronic antipsychotic administration are mediated by the dopamine D2 receptor

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
1053-8119
eISSN
1095-9572
D.O.I.
10.1016/j.neuroimage.2018.04.054
Publisher site
See Article on Publisher Site

Abstract

BackgroundNeuroanatomical alterations are well established in patients suffering from schizophrenia, however the extent to which these changes are attributable to illness, antipsychotic drugs (APDs), or their interaction is unclear. APDs have been extremely effective for treatment of positive symptoms in major psychotic disorders. Their therapeutic effects are mediated, in part, through blockade of D2-like dopamine (DA) receptors, i.e. the D2, D3 and D4 dopamine receptors. Furthermore, the dependency of neuroanatomical change on DA system function and D2-like receptors has yet to be explored.

Journal

NeuroimageElsevier

Published: Aug 1, 2018

References

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