Neuroscience Letters 664 (2018) 160–166 Contents lists available at ScienceDirect Neuroscience Letters journal homepage: www.elsevier.com/locate/neulet Research article Region-speciﬁc alterations in astrocyte and microglia morphology following exposure to blasts in the mouse hippocampus Gloria J. DeWalt , Biraaj Mahajan, Andrea R. Foster, Lauren D.E. Thompson, Andrew A. Marttini, Eric V. Schmidt, Sara Mansuri, Dwayne D’Souza, Shama B. Patel, Madeline Tenenbaum, Karla I. Brandao-Viruet, Dominique Thompson, Bryan Duong, Danica H. Smith, Todd A. Blute, William D. Eldred Boston University, Department of Biology, United States GR APHICAL A BSTRACT ARTICLE I NFO ABSTRACT Keywords: Traumatic brain injury (TBI) is a serious public health concern, especially injuries from repetitive insults. The Stratum lacunosm moleculare main objective of this study was to immunocytochemically examine morphological alterations in astrocytes and Outer molecular layer microglia in the hippocampus 48 h following a single blast versus multiple blasts in adult C57BL/6 mice. The Glia eﬀects of ketamine and xylazine (KX), two common anesthetic agents used in TBI research, were also evaluated Blast injury due to the confounding eﬀect of anesthetics on injury outcome. Results showed a signiﬁcant increase in hy- Ketamine/xylazine pertrophic microglia that was limited to the outer molecular layer of the dentate gyrus, but only
Neuroscience Letters – Elsevier
Published: Jan 18, 2018
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