Regenerative capacity of retinal ganglion cells in mammals

Regenerative capacity of retinal ganglion cells in mammals Retinal ganglion cells (RGCs) and their projections in the optic nerve offer a convenient model to study survival and regeneration of mammalian central nervous system (CNS) nerve cells following injury. Possible factors affecting the death of RGCs following axotomy and various approaches to rescue the axotomized RGCs are discussed. In addition, two main strategies currently used to enhance axonal regeneration of damaged RGCs are described. The first focuses on overcoming the unfavorable extrinsic CNS environment and the second concentrates on upregulating the intrinsic growth potential of RGCs. Thus, the failure or success of RGC axonal regrowth after injury depends on the complicated interplay between the extrinsic and intrinsic factors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Vision Research Elsevier

Regenerative capacity of retinal ganglion cells in mammals

Vision Research, Volume 38 (10) – May 1, 1998

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Publisher
Elsevier
Copyright
Copyright © 1998 Elsevier Science Ltd
ISSN
0042-6989
eISSN
1878-5646
DOI
10.1016/S0042-6989(97)00226-5
Publisher site
See Article on Publisher Site

Abstract

Retinal ganglion cells (RGCs) and their projections in the optic nerve offer a convenient model to study survival and regeneration of mammalian central nervous system (CNS) nerve cells following injury. Possible factors affecting the death of RGCs following axotomy and various approaches to rescue the axotomized RGCs are discussed. In addition, two main strategies currently used to enhance axonal regeneration of damaged RGCs are described. The first focuses on overcoming the unfavorable extrinsic CNS environment and the second concentrates on upregulating the intrinsic growth potential of RGCs. Thus, the failure or success of RGC axonal regrowth after injury depends on the complicated interplay between the extrinsic and intrinsic factors.

Journal

Vision ResearchElsevier

Published: May 1, 1998

References

  • Molecular mechanisms of developmental neuronal death
    Johnson, EM; Deckwerth, TL
  • Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation
    Martin, DP; Schmidt, RE; DiStefano, PS; Lowry, OH; Carter, JG; Johnson, EM
  • Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity
    Batistatou, A; Greene, LA
  • Excitotoxic cell death
    Choi, DW
  • Trophic factors produced by retinal cells increase the survival of retinal ganglion cells in vitro
    Araujo, EG; Linden, R
  • Immunolocalization of ciliary neuronotrophic factor in adult rat sciatic nerve
    Rende, M; Muir, D; Ruoslahti, E; Hagg, T; Varon, S; Manthorpe, M
  • The macrophage response to central and peripheral nerve injury. A possible role for macrophages in regeneration
    Perry, VH; Brown, MC; Gordon, S
  • Inhibition of mononuclear phagocytes reduces ischemic injury in the spinal cord
    Giulian, D; Robertson, C
  • The survival of neonatal rat retinal ganglion cells in vitro is enhanced in the presence of appropriate parts of the brain
    McCaffery, CA; Bennett, MR; Dreher, B
  • Immunohistological localization of tenascin in the developing and lesioned adult mouse optic nerve
    Bartsch, US; Bartsch, UD; Schachner, M
  • Myelin-associated glycoprotein inhibits neurite/axon growth and causes growth cone collapse
    Li, M; Shibata, A; Braun, PE; McKerracher, L; Roder, J; Kater, SB; David, S
  • Brain macrophages stimulate neurite growth and regeneration by secreting thrombospondin
    Chamak, B; Morandi, V; Mallat, M
  • Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA
    Meyer, M; Matsuoka, I; Wetmore, C; Olson, L; Thoenen, H
  • Altered expression of neuronal cell adhesion molecules induced by nerve injury and repair
    Daniloff, JK; Levi, G; Grumet, M; Rieger, F; Edelman, GM
  • Myelination of regenerated optic fibers in peripheral nerve graft of adult cats
    Watanabe, M; Sawai, H; Fukuda, Y
  • Alterations in the morphology of ganglion cell dendrites in the adult rat retina after optic nerve transection and grafting of peripheral nerve segments
    Thanos, S
  • Proportions of on-center versus off-center cells in retinal ganglion cells with regenerated axons of adult cats
    Watanabe, M; Fukuda, Y
  • Adult retinofugal axons regenerating through peripheral nerve grafts can restore the light-induced pupilloconstriction reflex
    Thanos, S
  • Light induced EEG desynchronization and behavioral arousal in rats with restored retinocollicular projection by peripheral nerve graft
    Sasaki, H; Coffey, P; Villegas-Perez, MP; Vidal-Sanz, M; Young, MJ; Lund, RD; Fukuda, Y
  • Adult retinal ganglion cells retain the ability to regenerate their axons up to several weeks after axotomy
    Thanos, S; Vanselow, J
  • Functional and morphological restoration of intracranial brachial lesion of the retinocollicular pathway by peripheral nerve autografts in adult hamsters
    Sawai, H; Sugioka, M; Morigiwa, K; Sasaki, H; So, KF; Fukuda, Y
  • Changes in axonally transported proteins during axon regeneration in toad retinal ganglion cells
    Skene, JH; Willard, M

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