Reduction of substance P after chronic antidepressants treatment in the striatum, substantia nigra and amygdala of the rat

Reduction of substance P after chronic antidepressants treatment in the striatum, substantia... We investigated the effects of chronic treatment with food containing one of five antidepressants on substance P (SP) content in the rat brain using radioimmunoassay and enzyme-immunoassay. The antidepressants used were imipramine, desipramine, clomipramine, amoxapine and mianserin. Following 40 days of treatment, all the antidepressants decreased SP concentrations in the striatum, substantia nigra and amygdala. Only imipramine and desipramine reduced the peptide content in the hippocampus, and only mianserin reduced it in the septum. We further examined the acute effects of antidepressants one hour after a single intraperitoneal administration. Acute imipramine and desipramine treatment reduced SP in the striatum, whereas acute mianserin decreased it in the striatum and substantia nigra. These results demonstrate that all antidepressants on chronic treatment had a common effect, a reduction of SP content in the striatum, substantia nigra and amygdala. This raises the possibility that such a decrease may contribute to the therapeutic action of antidepressants in affective disorders. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Elsevier

Reduction of substance P after chronic antidepressants treatment in the striatum, substantia nigra and amygdala of the rat

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Publisher
Elsevier
Copyright
Copyright © 1996 Elsevier Science B.V.
ISSN
0006-8993
DOI
10.1016/S0006-8993(96)00812-8
Publisher site
See Article on Publisher Site

Abstract

We investigated the effects of chronic treatment with food containing one of five antidepressants on substance P (SP) content in the rat brain using radioimmunoassay and enzyme-immunoassay. The antidepressants used were imipramine, desipramine, clomipramine, amoxapine and mianserin. Following 40 days of treatment, all the antidepressants decreased SP concentrations in the striatum, substantia nigra and amygdala. Only imipramine and desipramine reduced the peptide content in the hippocampus, and only mianserin reduced it in the septum. We further examined the acute effects of antidepressants one hour after a single intraperitoneal administration. Acute imipramine and desipramine treatment reduced SP in the striatum, whereas acute mianserin decreased it in the striatum and substantia nigra. These results demonstrate that all antidepressants on chronic treatment had a common effect, a reduction of SP content in the striatum, substantia nigra and amygdala. This raises the possibility that such a decrease may contribute to the therapeutic action of antidepressants in affective disorders.

Journal

Brain ResearchElsevier

Published: Nov 11, 1996

References

  • Perturbation of rat brain serotonergic systems results in an inverse relation between substance P and serotonin concentrations measured in discrete nuclei
    Barden, N.; Daigle, M.; Picard, V.; Di Paolo, T.
  • Chronic parenteral antidepressant treatment in rats: unaltered levels and processing of neuropeptide Y (NPY) and corticotropin-releasing hormone (CRH)
    Heilig, M.; Ekman, R.
  • Chronic dietary treatment with antidepressants decrease brain Met-enkephalin-like immunoreactivity in the rat
    Kurumaji, A.; Mitsushio, H.; Takashima, M.
  • A preliminary double-blind study on the efficacy of carbamazepine in prophylaxis of manic-depressive illness
    Okuma, T.; Inagaki, K.; Otsuki, S.; Sarai, K.; Takahashi, R.; Hazama, H.; Mori, A.; Watanabe, S.
  • Mianserin markedly and selectively increases extracellular dopamine in the prefrontal cortex as compared to the nucleus accumbens of the rat
    Tanda, G.; Bassareo, V.; Di Chiara, G.

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