Acta Biomaterialia 71 (2018) 339–350 Contents lists available at ScienceDirect Acta Biomaterialia journal homepage: www.elsevier.com/locate/actabiomat Full length article Recovery of low volumes of wear debris from rat stiﬂe joint tissues using a novel particle isolation method a,⇑ a b d b c a,c J. Patel , S. Lal , K. Nuss , S.P. Wilshaw , B. von Rechenberg , R.M. Hall , J.L. Tipper Faculty of Biological Sciences, University of Leeds, UK Musculoskeletal Research Unit, University of Zürich, Switzerland School of Mechanical Engineering, University of Leeds, UK School of Pharmacy and Medical Sciences, University of Bradford, UK article i nfo abstract Article history: Less than optimal particle isolation techniques have impeded analysis of orthopaedic wear debris in vivo. Received 12 November 2017 The purpose of this research was to develop and test an improved method for particle isolation from tis- Received in revised form 15 February 2018 3 sue. A volume of 0.018 mm of clinically relevant CoCrMo, Ti-6Al-4V or Si N particles was injected into 3 4 Accepted 19 February 2018 rat stiﬂe joints for seven days of in vivo exposure. Following sacriﬁce, particles were located within tissues Available online 2 March 2018 using histology. The particles were
Acta Biomaterialia – Elsevier
Published: Apr 15, 2018
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