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microelectrode was positioned in the NAc core, and DA oxidation currents (i.e., DA release ) evoked by brief stimulation of the medial forebrain bundle (MFB) were quantified before and after administration ...
2 to 5 h after reaching maximal CWS. Table 3 Equivalent Wake Enhancing Doses of Dopamine Releasing and Dopamine Transport Inhibiting Agents Treatment . Dose mg/kg . 4 h CWT min . MaxCWS min ...
responses to triangular current ramps injected after hyperpolarizing the neurons to halt spontaneous pacemaking. Current ramps with a peak of 50 pA did not evoke depolarization block, whereas those ...
(blue) and DEV (red) in the control condition (left panel), during dopamine application (middle panel), and after recovery (right panel). The application of dopamine caused an increment of the STD ...
of the first spike. The average number of evoked spikes in this group was 2.0 ± 0.3 (n = 25) before drug application. After ~5 min of baseline recording, NMDA (5–100 μM) was bath- applied for ~10 min. All ...
, thus demonstrating significant recovery (supplemental online Fig. 1). Figure 2. Open in new tabDownload slide Behavioral recovery after embryonic stem (ES)-cell-derived dopamine (DA) neuron grafting ...
A, Callicott JH, Adler C, Mattay V, Shapiro M, Frank JA, Pickar D, Weinberger DR ( 2000) The relationship between dorsolateral prefrontal neuronal N-acetylaspartate and evoked release of striatal dopamine ...
in two phases: a transient depression of evoked responses to below pre-tetanization values which persists for ~60 min following LFS, and a recovery of this response to a stable level of synaptic ...
from control values in any of the exposure groups (Table 2). However, GLU release evoked by high K+ stimulation in the presence of Ca+2 (a measure of total release ) was reduced by low levels of Pb ...
of reinforcement learning by the basal ganglia are based on simple dichotomies for cortical-striatal plasticity: that low and high dopamine respectively promote long-term depression (LTD) and long-term potentiation ...
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