Available online at www.sciencedirect.com ScienceDirect Recent advances in ion mobility–mass spectrometry for improved structural characterization of glycans and glycoconjugates 1,3 2,3 1,2 Zhengwei Chen , Matthew S Glover and Lingjun Li Glycans and glycoconjugates are involved in regulating a vast biosynthesis [2,3]. In addition, many of the monosacchar- array of cellular and molecular processes. Despite the ides that compose larger glycans are structural isomers, importance of glycans in biology and disease, characterization and they can be connected via either a-stereochemistry or of glycans remains difﬁcult due to their structural complexity b-stereochemistry at multiple linkage positions, resulting and diversity. Mass spectrometry (MS)-based techniques have in many glycan isomers (Figure 1a). Isomeric glycans can emerged as the premier analytical tools for characterizing also have a variety of connectivities to numerous sites on glycans. However, traditional MS-based strategies struggle to other classes of molecules such as proteins, contributing distinguish the large number of coexisting isomeric glycans that to their structural complexity (Figure 1b). are indistinguishable by mass alone. Because of this, ion mobility spectrometry coupled to MS (IM–MS) has received Separation and detailed structural characterization of considerable attention as an analytical tool for improving glycan or glycoconjugate isomers is crucial for under-
Current Opinion in Chemical Biology – Elsevier
Published: Feb 1, 2018
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