Article history: Current clinical treatment for mercury poisoning generally depends on the complexation of mercury ions Received 21 October 2017 with dithiol compounds. Although mercury is known to have a high binding afﬁnity for the soft sulfur Received in revised form 14 January 2018 donor atoms, further understanding of its complex formation tendencies in the presence of auxiliary Accepted 14 January 2018 donor atoms is necessary to enhance its immobilization and detoxiﬁcation. In order to evaluate the effect Available online 31 January 2018 of auxiliary binding groups on mercury complex formation, two dicysteinyl tripeptides, CXC, where C is cysteine and X is glycine (CGC) or glutamic acid (CEC) were reacted with mercury(II) chloride. These Keywords: peptides provide the structural differences to evaluate the role of an added gamma carboxylate group in Cysteinyl peptides complex formation. The reaction mixtures were studied by Electrospray Ionization Mass Spectrometry ESI mass spectrometry (ESI-MS). Low micromolar mercury(II) solutions consisting of mercury(II) to peptide molar ratio of 1:2, Mercury(II)–peptide complexes 1:1, and 1:0.5 were analyzed for changes in complex speciation after mixing. The results show that the Mercury isotopic patterns major complex formed is the 1:1 Hg(peptide) complex for both dithiol peptide ligands. Other complexes
International Journal of Mass Spectrometry – Elsevier
Published: Mar 1, 2018
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