Rational drug design and synthesis of new α-Santonin derivatives as potential COX-2 inhibitors

Rational drug design and synthesis of new α-Santonin derivatives as potential COX-2 inhibitors Bioorganic & Medicinal Chemistry Letters 28 (2018) 993–996 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Rational drug design and synthesis of new a-Santonin derivatives as potential COX-2 inhibitors a b c c b Adriana Coricello , Asma El-Magboub , Marian Luna , Angela Ferrario , Ian S. Haworth , c a,⇑ b Charles J. Gomer , Francesca Aiello , James D. Adams Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Edificio Polifunzionale, Università della Calabria, Arcavacata di Rende, 87036 Rende (CS), Italy Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles 90089, CA, USA Children’s Hospital Los Angeles, University of Southern California, 4650 W Sunset Boulevard, Los Angeles 90027, CA, USA article i nfo abstract Article history: Sesquiterpene compounds are widely known for their numerous pharmacological activities. Herein the Received 20 November 2017 focus of the authors was on a-Santonin, a sesquiterpene lactone from the Artemisia genus: the aim Revised 10 February 2018 was to determine whether a-Santonin could be considered in the treatment of inflammation and pain. Accepted 17 February 2018 To this purpose, a small series of derivatives was designed http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bioorganic & Medicinal Chemistry Letters Elsevier

Rational drug design and synthesis of new α-Santonin derivatives as potential COX-2 inhibitors

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0960-894x
D.O.I.
10.1016/j.bmcl.2018.02.036
Publisher site
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Abstract

Bioorganic & Medicinal Chemistry Letters 28 (2018) 993–996 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Rational drug design and synthesis of new a-Santonin derivatives as potential COX-2 inhibitors a b c c b Adriana Coricello , Asma El-Magboub , Marian Luna , Angela Ferrario , Ian S. Haworth , c a,⇑ b Charles J. Gomer , Francesca Aiello , James D. Adams Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Edificio Polifunzionale, Università della Calabria, Arcavacata di Rende, 87036 Rende (CS), Italy Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles 90089, CA, USA Children’s Hospital Los Angeles, University of Southern California, 4650 W Sunset Boulevard, Los Angeles 90027, CA, USA article i nfo abstract Article history: Sesquiterpene compounds are widely known for their numerous pharmacological activities. Herein the Received 20 November 2017 focus of the authors was on a-Santonin, a sesquiterpene lactone from the Artemisia genus: the aim Revised 10 February 2018 was to determine whether a-Santonin could be considered in the treatment of inflammation and pain. Accepted 17 February 2018 To this purpose, a small series of derivatives was designed

Journal

Bioorganic & Medicinal Chemistry LettersElsevier

Published: Apr 1, 2018

References

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