Bioorganic & Medicinal Chemistry Letters 28 (2018) 993–996 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Rational drug design and synthesis of new a-Santonin derivatives as potential COX-2 inhibitors a b c c b Adriana Coricello , Asma El-Magboub , Marian Luna , Angela Ferrario , Ian S. Haworth , c a,⇑ b Charles J. Gomer , Francesca Aiello , James D. Adams Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Ediﬁcio Polifunzionale, Università della Calabria, Arcavacata di Rende, 87036 Rende (CS), Italy Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles 90089, CA, USA Children’s Hospital Los Angeles, University of Southern California, 4650 W Sunset Boulevard, Los Angeles 90027, CA, USA article i nfo abstract Article history: Sesquiterpene compounds are widely known for their numerous pharmacological activities. Herein the Received 20 November 2017 focus of the authors was on a-Santonin, a sesquiterpene lactone from the Artemisia genus: the aim Revised 10 February 2018 was to determine whether a-Santonin could be considered in the treatment of inﬂammation and pain. Accepted 17 February 2018 To this purpose, a small series of derivatives was designed
Bioorganic & Medicinal Chemistry Letters – Elsevier
Published: Apr 1, 2018
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