Rat strain differences in the potentiation of morphine-induced analgesia by stress

Rat strain differences in the potentiation of morphine-induced analgesia by stress Restraint stress has been shown to increase the magnitude and duration of morphine-induced analgesia; however, this phenomenon has only been investigated using the Sprague-Dawley rat strain. The purpose of this study was to determine if other rat strains would also exhibit a potentiated analgesic response to morphine compared to their unrestrained controls. Dose-response and time course curves for the analgesic effect of morphine (1.0, 3.0, 5.6, 10 mg/kg) were generated in adult, male Wistar, Lewis, Fischer 344, Long-Evans Hooded, and Sprague-Dawley rats either unrestrained or restrained in Plexiglas cylinders, using the tail flick assay. Morphine produced dose-dependent increases in tail flick latencies, and this effect was potentiated by restraint stress in the Sprague-Dawley, Wistar, Lewis, and Fischer 344 strains, but not in the Long-Evans Hooded rats. Because Sprague-Dawley and Wistar rats displayed the most robust stress effect, the use of either of these rat strains is appropriate in studying the mechanisms of stress-induced potentiation of analgesia. The differences among rat strains demonstrated in this study may serve as a basis for correlation with opioid function. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmacology Biochemistry and Behavior Elsevier

Rat strain differences in the potentiation of morphine-induced analgesia by stress

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Ltd
ISSN
0091-3057
eISSN
1873-5177
DOI
10.1016/0091-3057(94)00440-T
Publisher site
See Article on Publisher Site

Abstract

Restraint stress has been shown to increase the magnitude and duration of morphine-induced analgesia; however, this phenomenon has only been investigated using the Sprague-Dawley rat strain. The purpose of this study was to determine if other rat strains would also exhibit a potentiated analgesic response to morphine compared to their unrestrained controls. Dose-response and time course curves for the analgesic effect of morphine (1.0, 3.0, 5.6, 10 mg/kg) were generated in adult, male Wistar, Lewis, Fischer 344, Long-Evans Hooded, and Sprague-Dawley rats either unrestrained or restrained in Plexiglas cylinders, using the tail flick assay. Morphine produced dose-dependent increases in tail flick latencies, and this effect was potentiated by restraint stress in the Sprague-Dawley, Wistar, Lewis, and Fischer 344 strains, but not in the Long-Evans Hooded rats. Because Sprague-Dawley and Wistar rats displayed the most robust stress effect, the use of either of these rat strains is appropriate in studying the mechanisms of stress-induced potentiation of analgesia. The differences among rat strains demonstrated in this study may serve as a basis for correlation with opioid function.

Journal

Pharmacology Biochemistry and BehaviorElsevier

Published: Aug 1, 1995

References

  • Fischer and Lewis rat strains differ in basal levels of neurofilament proteins and their regulation by chronic morphine in the mesolimbic dopamine system
    Guitart, X.; Beitner-Johnson, D.; Marby, D.W.; Kosten, T.A.; Nestler, E.J.

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