•Optimal parameters for generating stable inducible CHO pools expressing recombinant proteins were identified.•The CHO stable pool generation process is robust and can lead to pools expressing up to 800mg/L of r-proteins in a fed-batch process.•The pools are stable for over one month in culture and can be cryopreserved without losing productivity upon thawing.•Pools made with the cumate expression system outperform those generated with the CMV or the EF1a-HTLV hybrid promoters.
Journal of Biotechnology – Elsevier
Published: Aug 10, 2017
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