Molecular Immunology 95 (2018) 99–106 Contents lists available at ScienceDirect Molecular Immunology journal homepage: www.elsevier.com/locate/molimm Rapid induction of expression by LPS is accompanied by favorable chromatin and rapid binding of c-Jun Kelly Maurer, Swathi Ramen, Lihuaa Shi, Li Song, Kathleen E. Sullivan The Children’s Hospital of Philadelphia, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA ARTICLE I NFO ABSTRACT Keywords: The response to infection is managed in mammals by a coordinated immune response. Innate responses are rapid Endotoxin and hard wired and have been demonstrated to be regulated at the level of chromatin accessibility. This study Enhancer examined primary human monocyte responses to LPS as a model of innate responses to bacteria. We utilized Histone modiﬁcations inhibitors of chromatin modifying enzymes to understand the inter-relationships of the chromatin complexes Pause-release regulating transcription. Multiplex digital gene detection was utilized to quantitate changes in mRNA levels for Transcription genes induced by LPS. In the ﬁrst 30 min, genes that were highly induced by LPS as a group exhibited minimal eﬀect of the chemical inhibitors of chromatin modiﬁcations. At 60 min, the more highly expressed genes were markedly more inhibitable. The eﬀects of the inhibitors were almost entirely concordant in
Molecular Immunology – Elsevier
Published: Mar 1, 2018
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