Rapid induction of expression by LPS is accompanied by favorable chromatin and rapid binding of c-Jun

Rapid induction of expression by LPS is accompanied by favorable chromatin and rapid binding of... Molecular Immunology 95 (2018) 99–106 Contents lists available at ScienceDirect Molecular Immunology journal homepage: www.elsevier.com/locate/molimm Rapid induction of expression by LPS is accompanied by favorable chromatin and rapid binding of c-Jun Kelly Maurer, Swathi Ramen, Lihuaa Shi, Li Song, Kathleen E. Sullivan The Children’s Hospital of Philadelphia, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA ARTICLE I NFO ABSTRACT Keywords: The response to infection is managed in mammals by a coordinated immune response. Innate responses are rapid Endotoxin and hard wired and have been demonstrated to be regulated at the level of chromatin accessibility. This study Enhancer examined primary human monocyte responses to LPS as a model of innate responses to bacteria. We utilized Histone modifications inhibitors of chromatin modifying enzymes to understand the inter-relationships of the chromatin complexes Pause-release regulating transcription. Multiplex digital gene detection was utilized to quantitate changes in mRNA levels for Transcription genes induced by LPS. In the first 30 min, genes that were highly induced by LPS as a group exhibited minimal effect of the chemical inhibitors of chromatin modifications. At 60 min, the more highly expressed genes were markedly more inhibitable. The effects of the inhibitors were almost entirely concordant in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Immunology Elsevier

Rapid induction of expression by LPS is accompanied by favorable chromatin and rapid binding of c-Jun

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Publisher
Pergamon
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0161-5890
D.O.I.
10.1016/j.molimm.2018.02.002
Publisher site
See Article on Publisher Site

Abstract

Molecular Immunology 95 (2018) 99–106 Contents lists available at ScienceDirect Molecular Immunology journal homepage: www.elsevier.com/locate/molimm Rapid induction of expression by LPS is accompanied by favorable chromatin and rapid binding of c-Jun Kelly Maurer, Swathi Ramen, Lihuaa Shi, Li Song, Kathleen E. Sullivan The Children’s Hospital of Philadelphia, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA ARTICLE I NFO ABSTRACT Keywords: The response to infection is managed in mammals by a coordinated immune response. Innate responses are rapid Endotoxin and hard wired and have been demonstrated to be regulated at the level of chromatin accessibility. This study Enhancer examined primary human monocyte responses to LPS as a model of innate responses to bacteria. We utilized Histone modifications inhibitors of chromatin modifying enzymes to understand the inter-relationships of the chromatin complexes Pause-release regulating transcription. Multiplex digital gene detection was utilized to quantitate changes in mRNA levels for Transcription genes induced by LPS. In the first 30 min, genes that were highly induced by LPS as a group exhibited minimal effect of the chemical inhibitors of chromatin modifications. At 60 min, the more highly expressed genes were markedly more inhibitable. The effects of the inhibitors were almost entirely concordant in

Journal

Molecular ImmunologyElsevier

Published: Mar 1, 2018

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