Bioorganic & Medicinal Chemistry Letters 28 (2018) 1143–1148 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Radiosynthesis and biological evaluation of F-labeled 4-anilinoquinazoline derivative ( F-FEA-Erlotinib) as a potential EGFR PET agent a,b b a b b b b Shun Huang , Yanjiang Han , Min Chen , Kongzhen Hu , Yongshuai Qi , Penghui Sun , Men Wang , b b b a a,c a,⇑ a,⇑ Hubing Wu , Guiping Li , Quanshi Wang , Zhiyun Du , Kun Zhang , Suqing Zhao , Xi Zheng Department of Pharmaceutical Engineering, Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, Guangdong 510006, China Nanfang PET Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China Department of Chemical and Environmental Engineering, Wuyi University, Jiangmen, Guangdong 529020, China article i nfo abstract Article history: Epidermal growth factor receptor (EGFR) has gained signiﬁcant attention as a therapeutic target. Several Received 15 May 2017 EGFR targeting drugs (Geﬁtinib and Erlotinib) have been approved by US Food and Drug Administration Revised 18 August 2017 (FDA) and have received high approval in clinical treatment. Nevertheless, the curative effect of these Accepted 25 August 2017 medicines varied
Bioorganic & Medicinal Chemistry Letters – Elsevier
Published: Apr 1, 2018
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