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sensitive to DPI than cytochrome c reductase activity (Table 1 and Figure 2 ; IC50 = 0.62 μM using 7-ethoxycoumarin as the substrate and 0.99 µM using p-nitrophenol as the substrate vs 15.70 μM). It should ...
. These properties distinguish the enzyme from alcohol dehydrogenase, quinone reductase and rat liver DID. Rn human lung, DD activity was barely detectable using a sensitive radiochemical assay in which the oxidation ...
distinguished P1-ZCr from AKR (Burczynski et al. 2001). On the other hand, 2 -alkenones, such as 3-buten- 2 -one and 3-penten- 2 -one, also were good substrates . Thus P1-ZCr appears specific to a double bond activated ...
been shown to be a site of oxidative metabolism of estrogen due to the presence of specific cytochrome P450 enzymes. The oxidative metabolism of 17 β-estradiol (E2) to E2–3,4- quinone metabolites by an E2 ...
Subsequently the formation of o- quinones was observed for estrone (E1) and 17β-estradiol (E2). Hydroxylation of E1 and E2 leads to the formation of the catechol estrogens: 2 -hydroxy-estrone (E1)/estradiol (E2 ...
as a purine nucleoside (inosine or guanosine) and is inhibited by thiol reagents, the AsV analogue phosphate, and purine bases. Characterization of this AsV reductase activity led us to identification ...
biochemical characterization of one isoform, LePGT1, revealed that the N-terminal 130 amino acids are responsible for its specificity for GPP109 and that it is inhibited by aromatic substrates with two phenolic ...
. Hepatic GST specific activities were determined spectrophotometrically by monitoring metabolism of the 1-chloro-2,4-dinitrobenzene substrate at 340 nm over 2 min as previously described (Habig et al., 1974 ...
of PAHs, involving the (1) diol epoxide path (Conney, 1982; Jeffrey et al., 1977; Jennette et al., 1977; Sims et al., 1974; Wood et al., 1976), ( 2 ) the quinone path (Smithgall et al., 1986, 1988a,b), and (3 ...
enzymes . Arch Pharm (Weinheim) 2018 ; 351(12) : e1800263 . Google Scholar OpenURL Placeholder Text WorldCat Demir Y et al. Inhibition effects of quinones on aldose reductase : antidiabetic properties ...
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