Quetiapine as add-on treatment for bipolar I disorder with comorbid compulsive buying and physical exercise addiction

Quetiapine as add-on treatment for bipolar I disorder with comorbid compulsive buying and... 1 <h5>Introduction</h5> Quetiapine is a second generation antipsychotic that shows affinity for various neurotransmitter receptors: specifically the D1 and D2 dopamine receptor, the alpha-1 and alpha-2 adrenergic receptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. In the bipolar spectrum disorders quetiapine is approved for the treatment of acute manic and mixed episodes associated with bipolar I disorder ( Bowden et al., 2005; Brahm et al., 2007 ). It is also approved for the treatment of acute bipolar depressive episodes and as adjunctive maintenance therapy of bipolar I disorder with lithium or valproate ( Thase et al., 2006; Vieta et al., 2008; Suppes et al., 2009 ). In a previous study we reported the high frequency of association between bipolar disorder and behavioural addictions ( Di Nicola et al., in press ) and the correlation with high level of impulsivity and specific temperamental and character dimensions. We underlined that the assessment of behavioural addictions in bipolar disorder patients may have a direct impact on the choice of pharmacological and psycho-educative interventions aimed at reducing harmful behaviours and the risk of relapses. The present case report deals with the potential use of quetiapine as add-on treatment for bipolar http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Progress in Neuro-Psychopharmacology & Biological Psychiatry Elsevier

Quetiapine as add-on treatment for bipolar I disorder with comorbid compulsive buying and physical exercise addiction

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Publisher
Elsevier
Copyright
Copyright © 2010 Elsevier Inc.
ISSN
0278-5846
eISSN
1878-4216
DOI
10.1016/j.pnpbp.2010.03.013
Publisher site
See Article on Publisher Site

Abstract

1 <h5>Introduction</h5> Quetiapine is a second generation antipsychotic that shows affinity for various neurotransmitter receptors: specifically the D1 and D2 dopamine receptor, the alpha-1 and alpha-2 adrenergic receptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. In the bipolar spectrum disorders quetiapine is approved for the treatment of acute manic and mixed episodes associated with bipolar I disorder ( Bowden et al., 2005; Brahm et al., 2007 ). It is also approved for the treatment of acute bipolar depressive episodes and as adjunctive maintenance therapy of bipolar I disorder with lithium or valproate ( Thase et al., 2006; Vieta et al., 2008; Suppes et al., 2009 ). In a previous study we reported the high frequency of association between bipolar disorder and behavioural addictions ( Di Nicola et al., in press ) and the correlation with high level of impulsivity and specific temperamental and character dimensions. We underlined that the assessment of behavioural addictions in bipolar disorder patients may have a direct impact on the choice of pharmacological and psycho-educative interventions aimed at reducing harmful behaviours and the risk of relapses. The present case report deals with the potential use of quetiapine as add-on treatment for bipolar

Journal

Progress in Neuro-Psychopharmacology & Biological PsychiatryElsevier

Published: May 30, 2010

References

  • Psychometric properties of an Italian version of the Barratt Impulsiveness Scale-11 (BIS-11) in nonclinical subjects
    Fossati, A.; Di Ceglie, A.; Acquarini, E.; Barratt, E.S.
  • A web of dependence
    Gossop, M.

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