1 <h5>Introduction</h5> Quetiapine is a second generation antipsychotic that shows affinity for various neurotransmitter receptors: specifically the D1 and D2 dopamine receptor, the alpha-1 and alpha-2 adrenergic receptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. In the bipolar spectrum disorders quetiapine is approved for the treatment of acute manic and mixed episodes associated with bipolar I disorder ( Bowden et al., 2005; Brahm et al., 2007 ). It is also approved for the treatment of acute bipolar depressive episodes and as adjunctive maintenance therapy of bipolar I disorder with lithium or valproate ( Thase et al., 2006; Vieta et al., 2008; Suppes et al., 2009 ). In a previous study we reported the high frequency of association between bipolar disorder and behavioural addictions ( Di Nicola et al., in press ) and the correlation with high level of impulsivity and specific temperamental and character dimensions. We underlined that the assessment of behavioural addictions in bipolar disorder patients may have a direct impact on the choice of pharmacological and psycho-educative interventions aimed at reducing harmful behaviours and the risk of relapses. The present case report deals with the potential use of quetiapine as add-on treatment for bipolar
Progress in Neuro-Psychopharmacology & Biological Psychiatry – Elsevier
Published: May 30, 2010
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