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levels of the CLOCK (p=0.050), BMAL1 (p=0.001) and CRY1 (p=0.040) genes , compared with controls. Within the cases, analysis of the effects of shift work on the methylation patterns showed that methylation ...
Epigenetic clocks for mice were generated based on deep-sequencing analysis of the methylome. Here, we demonstrate that site-specific analysis of DNA methylation levels by pyrosequencing at only ...
expression at daytime oscillation in the examined groups. Pyrosequencing revealed daytime changes in the methylation level of regulatory sites of the examined sequence. Luciferase reporter assay confirmed ...
patients and 60 healthy controls using the Infinium Human Methylation 450 K Beadchip. BD-associated methylation loci were validated in 100 BD patients and 100 healthy controls by pyrosequencing . Gene ...
stable epigenetic mechanism in mammals. It is important in the regulation of gene expression and maintaining genome stability locally and at the global level .1,2 Changes in methylation occur in utero ...
) Pyrosequencing Candidate gene ( CLOCK ) Departure from wintering grounds, arrival on breeding grounds, timing of reproduction, breeding success Whole blood Watson et al. 2019 Great tit (P. major) Methylation ...
WorldCat 38. Absher DM , Li X, Waite LL, Gibson A, Roberts K, Edberg J , et al. Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes ...
the substantial heterogeneity within tumors described for gene expression, treatment response, etcetera, we asked whether intratumor heterogeneity in GBM exists also at the level of DNA methylation . This knowledge ...
Introduction Epigenetic clocks allow for the prediction and observation of biological aging [1]. By profiling the methylation levels at specific sites in DNA, it is possible to accurately predict ...
methylation levels occur at CpG sites (where a cytosine is next to a guanine in the DNA sequence). Clusters of these sites are called CpG islands and are often observed in the promoter of the gene [24 ...
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