PrPC expression and calpain activity independently mediate the effects of closed head injury in mice

PrPC expression and calpain activity independently mediate the effects of closed head injury in mice •Head trauma induces calpain hyperactivation in neurons and glial cells.•Calpain activation results in spectrin and GFAP breakdown products (BDPs).•SNJ-1945 inhibits calpain following neurotrauma and reduces the levels of BDPs.•PrPC is resistant to calpain and not affected by CHI-induced calpain activation.•CHI is not affected by, nor does it have an influence on, PrPC expression. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Behavioural Brain Research Elsevier

PrPC expression and calpain activity independently mediate the effects of closed head injury in mice

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Publisher
Elsevier
Copyright
Copyright © 2016 Elsevier B.V.
ISSN
0166-4328
D.O.I.
10.1016/j.bbr.2016.04.041
Publisher site
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Abstract

•Head trauma induces calpain hyperactivation in neurons and glial cells.•Calpain activation results in spectrin and GFAP breakdown products (BDPs).•SNJ-1945 inhibits calpain following neurotrauma and reduces the levels of BDPs.•PrPC is resistant to calpain and not affected by CHI-induced calpain activation.•CHI is not affected by, nor does it have an influence on, PrPC expression.

Journal

Behavioural Brain ResearchElsevier

Published: Mar 15, 2018

References

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