Proximity effects in chromosome aberration induction: Dependence on radiation quality, cell type and dose

Proximity effects in chromosome aberration induction: Dependence on radiation quality, cell type... •The distance-dependence of chromosome fragment end-joining probability was studied.•In lymphocytes, such dependence was reproduced by a negative exponential function.•Such exponential function is consistent with fragment free-end diffusion.•In fibroblasts, the exponential model underestimated interstitial deletions.•The high yields of interstitial deletions may also be related to the cell dimensions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png DNA Repair Elsevier

Proximity effects in chromosome aberration induction: Dependence on radiation quality, cell type and dose

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier B.V.
ISSN
1568-7864
D.O.I.
10.1016/j.dnarep.2018.02.006
Publisher site
See Article on Publisher Site

Abstract

•The distance-dependence of chromosome fragment end-joining probability was studied.•In lymphocytes, such dependence was reproduced by a negative exponential function.•Such exponential function is consistent with fragment free-end diffusion.•In fibroblasts, the exponential model underestimated interstitial deletions.•The high yields of interstitial deletions may also be related to the cell dimensions.

Journal

DNA RepairElsevier

Published: Apr 1, 2018

References

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