Proteolysis and the cell cycle: with this RING I do thee destroy

Proteolysis and the cell cycle: with this RING I do thee destroy The ubiquitin system drives the cell division cycle by the timely destruction of numerous regulatory proteins. Remarkably, the two main activities that catalyze substrate ubiquitination in the cell cycle, the Skp1–Cdc53/cullin–F-box protein (SCF) complexes and the anaphase-promoting complex/cyclosome (APC/C), define a new superfamily of E3 ubiquitin ligases, all based on related cullin and RING-H2 finger protein subunits. The circuits that interconnect the SCF, APC/C and cyclin-dependent kinase activities form a master oscillator that coordinates the replication and segregation of the genome. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Genetics & Development Elsevier

Proteolysis and the cell cycle: with this RING I do thee destroy

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Publisher
Elsevier
Copyright
Copyright © 2000 Elsevier Science Ltd
ISSN
0959-437x
D.O.I.
10.1016/S0959-437X(99)00049-0
Publisher site
See Article on Publisher Site

Abstract

The ubiquitin system drives the cell division cycle by the timely destruction of numerous regulatory proteins. Remarkably, the two main activities that catalyze substrate ubiquitination in the cell cycle, the Skp1–Cdc53/cullin–F-box protein (SCF) complexes and the anaphase-promoting complex/cyclosome (APC/C), define a new superfamily of E3 ubiquitin ligases, all based on related cullin and RING-H2 finger protein subunits. The circuits that interconnect the SCF, APC/C and cyclin-dependent kinase activities form a master oscillator that coordinates the replication and segregation of the genome.

Journal

Current Opinion in Genetics & DevelopmentElsevier

Published: Feb 1, 2000

References

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