Article history: In the present study, the properties of hydrogel systems based on hyaluronic acid (HA)-hydroxyethyl Received 27 February 2016 cellulose (HEC) were investigated for effective transdermal delivery of isoliquiritigenin (ILTG). Hydrogels Received in revised form 5 April 2016 were synthesized by chemical cross-linking, and network structures were characterised using scanning Accepted 6 April 2016 electron microscopy (SEM) and surface area analyser. Texture properties and swelling of HA-HEC hydro- Available online 8 April 2016 gels were found to be closely linked to cross-linker concentration and swelling medium. Water in HA-HEC hydrogels was found to exist mostly in the form of free water. The viscoelasticity and the network sta- Chemical compounds studied in this article: bilization of the hydrogels were analysed via rheological studies. The release kinetics of the hydrogel Hyaluronic acid (PubChem CID: 24728612) followed Fickian diffusion mechanism. In an in vitro skin penetration study, the system substantially Hydroxyethyl cellulose (PubChem CID: improved the delivery of ILTG into the skin. These results indicate that the hydrogel system composed of 24846132) HA and HEC has potential as a transdermal delivery system, with cross-linking density and the swelling Isoliquiritigenin (PubChem CID: 638278) Divinyl sulfone (PubChem CID: 6496) medium inﬂuencing the properties.
Carbohydrate Polymers – Elsevier
Published: Aug 20, 2016
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