Prolonged administration of NT-4/5 fails to rescue most axotomized retinal ganglion cells in adult rats

Prolonged administration of NT-4/5 fails to rescue most axotomized retinal ganglion cells in... The survival of axotomized RGCs was increased by intravitreal NT-4/5 given by repeated injections or osmotic minipumps, but the effects were less complete than predicted. Compared to a single injection of the neurotrophin on day 0, second injections on days 3 or 7 only sustained an additional 10–20% of the RGCs on day 10. Minipumps augmented RGC survival up to 4-fold (50%) at 2 weeks but most RGCs were lost by 1 month. Thus, specific neurotrophins can rescue many RGCs soon after injury but long-term neuronal survival may require a better understanding of changes in neurotrophin receptors and interactions with other molecules. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Vision Research Elsevier

Prolonged administration of NT-4/5 fails to rescue most axotomized retinal ganglion cells in adult rats

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Publisher
Elsevier
Copyright
Copyright © 1998 Elsevier Science Ltd
ISSN
0042-6989
eISSN
1878-5646
DOI
10.1016/S0042-6989(97)00341-6
Publisher site
See Article on Publisher Site

Abstract

The survival of axotomized RGCs was increased by intravitreal NT-4/5 given by repeated injections or osmotic minipumps, but the effects were less complete than predicted. Compared to a single injection of the neurotrophin on day 0, second injections on days 3 or 7 only sustained an additional 10–20% of the RGCs on day 10. Minipumps augmented RGC survival up to 4-fold (50%) at 2 weeks but most RGCs were lost by 1 month. Thus, specific neurotrophins can rescue many RGCs soon after injury but long-term neuronal survival may require a better understanding of changes in neurotrophin receptors and interactions with other molecules.

Journal

Vision ResearchElsevier

Published: May 1, 1998

References

  • Neurotrophin-4/5 postpones the death of injured spinal motoneurons in newborn rats
    Schmalbruch, H.; Rosenthal, A.
  • Quantitative comparison of the transient rescue effects of neurotrophic factors on axotomized motoneurons in vivo
    Vejsada, R.; Sagot, Y.; Kato, A.C.

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