Production of 1,3-propanediol by Clostridium beijerinckii DSM 791 from crude glycerol and corn steep liquor: Process optimization and metabolic engineering

Production of 1,3-propanediol by Clostridium beijerinckii DSM 791 from crude glycerol and corn... •C. beijerinckii DSM 791 is a robust organism for 1,3-PDO production from glycerol.•Replacing yeast extract with corn steep liquor increased cell growth and productivity.•Stable, long-term 1,3-PDO production was obtained in repeated batch fermentations.•Cell was engineered to overexpress GDH and DHAK.•1,3-PDO productivity increased 26.8–37.5% with a greatly increased growth rate. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bioresource Technology Elsevier

Production of 1,3-propanediol by Clostridium beijerinckii DSM 791 from crude glycerol and corn steep liquor: Process optimization and metabolic engineering

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Publisher
Elsevier
Copyright
Copyright © 2016 Elsevier Ltd
ISSN
0960-8524
D.O.I.
10.1016/j.biortech.2016.04.020
Publisher site
See Article on Publisher Site

Abstract

•C. beijerinckii DSM 791 is a robust organism for 1,3-PDO production from glycerol.•Replacing yeast extract with corn steep liquor increased cell growth and productivity.•Stable, long-term 1,3-PDO production was obtained in repeated batch fermentations.•Cell was engineered to overexpress GDH and DHAK.•1,3-PDO productivity increased 26.8–37.5% with a greatly increased growth rate.

Journal

Bioresource TechnologyElsevier

Published: Jul 1, 2016

References

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