Processing ulvan into 2D structures: Cross-linked ulvan membranes as new biomaterials for drug delivery applications

Processing ulvan into 2D structures: Cross-linked ulvan membranes as new biomaterials for drug... Article history: The polysaccharide ulvan, composed of sulphated rhamnose, glucoronic and iduronic acids was used Received 28 October 2011 to produce polymeric membranes by solvent casting. As ulvan is soluble in water, a cross-linking step Received in revised form 9 January 2012 was necessary to render the membrane insoluble in water and stable at physiological conditions. Cross- Accepted 10 January 2012 linked ulvan membranes were characterized by FTIR, SEM, swelling behaviour was investigated and the Available online 18 January 2012 mechanical performance assessed by quasi-static tensile testing. Furthermore, the ability and mecha- nism of sustained release of a model drug from ulvan membranes was investigated. Produced membranes Keywords: revealed remarkable ability to uptake water (up to ∼1800% of its initial dry weight) and increased mechan- Ulvan ical performance (1.76 MPa) related with cross-linking. On the other hand, medicated ulvan dressings Membrane demonstrate the potential as drug delivery devices. Using a model drug we have observed an initial Dressing steady release of the drug – of nearly 49% – followed by slower and sustained release up to 14 days. Medicated dressing Drug delivery The properties of ulvan membranes herein revealed suggest a great potential of this natural sulphated polysaccharide as http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Pharmaceutics Elsevier

Processing ulvan into 2D structures: Cross-linked ulvan membranes as new biomaterials for drug delivery applications

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Publisher
Elsevier
Copyright
Copyright © 2012 Elsevier B.V.
ISSN
0378-5173
D.O.I.
10.1016/j.ijpharm.2012.01.021
Publisher site
See Article on Publisher Site

Abstract

Article history: The polysaccharide ulvan, composed of sulphated rhamnose, glucoronic and iduronic acids was used Received 28 October 2011 to produce polymeric membranes by solvent casting. As ulvan is soluble in water, a cross-linking step Received in revised form 9 January 2012 was necessary to render the membrane insoluble in water and stable at physiological conditions. Cross- Accepted 10 January 2012 linked ulvan membranes were characterized by FTIR, SEM, swelling behaviour was investigated and the Available online 18 January 2012 mechanical performance assessed by quasi-static tensile testing. Furthermore, the ability and mecha- nism of sustained release of a model drug from ulvan membranes was investigated. Produced membranes Keywords: revealed remarkable ability to uptake water (up to ∼1800% of its initial dry weight) and increased mechan- Ulvan ical performance (1.76 MPa) related with cross-linking. On the other hand, medicated ulvan dressings Membrane demonstrate the potential as drug delivery devices. Using a model drug we have observed an initial Dressing steady release of the drug – of nearly 49% – followed by slower and sustained release up to 14 days. Medicated dressing Drug delivery The properties of ulvan membranes herein revealed suggest a great potential of this natural sulphated polysaccharide as

Journal

International Journal of PharmaceuticsElsevier

Published: Apr 15, 2012

References

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