Processing ulvan into 2D structures: Cross-linked ulvan membranes as new biomaterials for drug delivery applications

Processing ulvan into 2D structures: Cross-linked ulvan membranes as new biomaterials for drug... Article history: The polysaccharide ulvan, composed of sulphated rhamnose, glucoronic and iduronic acids was used Received 28 October 2011 to produce polymeric membranes by solvent casting. As ulvan is soluble in water, a cross-linking step Received in revised form 9 January 2012 was necessary to render the membrane insoluble in water and stable at physiological conditions. Cross- Accepted 10 January 2012 linked ulvan membranes were characterized by FTIR, SEM, swelling behaviour was investigated and the Available online 18 January 2012 mechanical performance assessed by quasi-static tensile testing. Furthermore, the ability and mecha- nism of sustained release of a model drug from ulvan membranes was investigated. Produced membranes Keywords: revealed remarkable ability to uptake water (up to ∼1800% of its initial dry weight) and increased mechan- Ulvan ical performance (1.76 MPa) related with cross-linking. On the other hand, medicated ulvan dressings Membrane demonstrate the potential as drug delivery devices. Using a model drug we have observed an initial Dressing steady release of the drug – of nearly 49% – followed by slower and sustained release up to 14 days. Medicated dressing Drug delivery The properties of ulvan membranes herein revealed suggest a great potential of this natural sulphated polysaccharide as http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Pharmaceutics Elsevier

Processing ulvan into 2D structures: Cross-linked ulvan membranes as new biomaterials for drug delivery applications

Loading next page...
 
/lp/elsevier/processing-ulvan-into-2d-structures-cross-linked-ulvan-membranes-as-Us4jXifnvr
Publisher
Elsevier
Copyright
Copyright © 2012 Elsevier B.V.
ISSN
0378-5173
D.O.I.
10.1016/j.ijpharm.2012.01.021
Publisher site
See Article on Publisher Site

Abstract

Article history: The polysaccharide ulvan, composed of sulphated rhamnose, glucoronic and iduronic acids was used Received 28 October 2011 to produce polymeric membranes by solvent casting. As ulvan is soluble in water, a cross-linking step Received in revised form 9 January 2012 was necessary to render the membrane insoluble in water and stable at physiological conditions. Cross- Accepted 10 January 2012 linked ulvan membranes were characterized by FTIR, SEM, swelling behaviour was investigated and the Available online 18 January 2012 mechanical performance assessed by quasi-static tensile testing. Furthermore, the ability and mecha- nism of sustained release of a model drug from ulvan membranes was investigated. Produced membranes Keywords: revealed remarkable ability to uptake water (up to ∼1800% of its initial dry weight) and increased mechan- Ulvan ical performance (1.76 MPa) related with cross-linking. On the other hand, medicated ulvan dressings Membrane demonstrate the potential as drug delivery devices. Using a model drug we have observed an initial Dressing steady release of the drug – of nearly 49% – followed by slower and sustained release up to 14 days. Medicated dressing Drug delivery The properties of ulvan membranes herein revealed suggest a great potential of this natural sulphated polysaccharide as

Journal

International Journal of PharmaceuticsElsevier

Published: Apr 15, 2012

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off