Privileged portal metastasis of hepatocellular carcinoma in light of co-evolution of a visceral portal system and the liver in the chordate lineage: a search for therapeutic targets

Privileged portal metastasis of hepatocellular carcinoma in light of co-evolution of a visceral... •HCC disseminates systemically via hepatic veins but paradoxically metastasizes more often to portal veins.•The “portal paradox” becomes a logical event in light of co-evolution of a portal system and the liver in chordate lineage.•The portal system carrying pancreatic family hormones/growth factors (PHGFs) occurs prior to the liver in chordate evolution.•Acquiring liver, hepatocyte differentiation, HCC portal metastasis and selection more aggressive clones are PHGFs-dependent.•PHGFs of portal blood and their ligands constitute therapeutic targets for prevention/cure of HCC metastatic dissemination. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Drug Discovery Today Elsevier

Privileged portal metastasis of hepatocellular carcinoma in light of co-evolution of a visceral portal system and the liver in the chordate lineage: a search for therapeutic targets

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
1359-6446
D.O.I.
10.1016/j.drudis.2018.01.020
Publisher site
See Article on Publisher Site

Abstract

•HCC disseminates systemically via hepatic veins but paradoxically metastasizes more often to portal veins.•The “portal paradox” becomes a logical event in light of co-evolution of a portal system and the liver in chordate lineage.•The portal system carrying pancreatic family hormones/growth factors (PHGFs) occurs prior to the liver in chordate evolution.•Acquiring liver, hepatocyte differentiation, HCC portal metastasis and selection more aggressive clones are PHGFs-dependent.•PHGFs of portal blood and their ligands constitute therapeutic targets for prevention/cure of HCC metastatic dissemination.

Journal

Drug Discovery TodayElsevier

Published: Mar 1, 2018

References

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