Prevention by 5-HT 1A receptor agonists of restraint stress- and yohimbine-induced release of cholecystokinin in the frontal cortex of the freely moving rat

Prevention by 5-HT 1A receptor agonists of restraint stress- and yohimbine-induced release of... In line with the idea that cholecystokinin (CCK) is involved in anxiety-related behaviours, previous investigations showed that stressful conditions and an ‘anxiogenic’ drug, yohimbine, increased the cortical release of CCK like-material (CCKLM) in awake rats, and that this effect could be prevented by diazepam. Here, we investigated whether other anxiolytic drugs such as 5-HT 1A receptor agonists could also affect cortical CCKLM release. Indeed, neither buspirone (1 mg/kg i.p.), alnespirone (1 mg/kg i.p.) nor lesopitron (3 mg/kg i.p.) affected, on their own, CCKLM release. However, pretreatment with the latter drugs completely abolished the stimulatory effect of restraint stress on the peptide outflow. As expected of the involvement of 5-HT 1A receptors, tertatolol (10 mg/kg i.p) markedly reduced the inhibitory effect of buspirone on restraint stress-evoked CCKLM overflow. On the other hand, pretreatment with buspirone, alnespirone or lesopitron also inhibited the stimulatory effect of yohimbine (5 mg/kg i.p.) on cortical CCKLM outflow. These data support the idea that the anxiolytic action of 5-HT 1A receptor agonists could be mediated, at least partly, through their inhibitory influence on cortical CCK-ergic systems. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuropharmacology Elsevier

Prevention by 5-HT 1A receptor agonists of restraint stress- and yohimbine-induced release of cholecystokinin in the frontal cortex of the freely moving rat

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Publisher
Elsevier
Copyright
Copyright © 1999 Elsevier Science Ltd
ISSN
0028-3908
eISSN
1873-7064
DOI
10.1016/S0028-3908(98)00209-3
Publisher site
See Article on Publisher Site

Abstract

In line with the idea that cholecystokinin (CCK) is involved in anxiety-related behaviours, previous investigations showed that stressful conditions and an ‘anxiogenic’ drug, yohimbine, increased the cortical release of CCK like-material (CCKLM) in awake rats, and that this effect could be prevented by diazepam. Here, we investigated whether other anxiolytic drugs such as 5-HT 1A receptor agonists could also affect cortical CCKLM release. Indeed, neither buspirone (1 mg/kg i.p.), alnespirone (1 mg/kg i.p.) nor lesopitron (3 mg/kg i.p.) affected, on their own, CCKLM release. However, pretreatment with the latter drugs completely abolished the stimulatory effect of restraint stress on the peptide outflow. As expected of the involvement of 5-HT 1A receptors, tertatolol (10 mg/kg i.p) markedly reduced the inhibitory effect of buspirone on restraint stress-evoked CCKLM overflow. On the other hand, pretreatment with buspirone, alnespirone or lesopitron also inhibited the stimulatory effect of yohimbine (5 mg/kg i.p.) on cortical CCKLM outflow. These data support the idea that the anxiolytic action of 5-HT 1A receptor agonists could be mediated, at least partly, through their inhibitory influence on cortical CCK-ergic systems.

Journal

NeuropharmacologyElsevier

Published: Apr 1, 1999

References

  • The profiles of interaction of yohimbine with anxiolytic and putative anxiolytic agents to modify 5-HT release in the frontal cortex of freely-moving rats
    Cheng, C.H.K.; Costall, B.; Ge, J.; Naylor, R.J.
  • Anxiolytic effects of CCK-B antagonists
    Costall, B.; Domeney, A.M.; Hughes, J.; Kelly, M.E.; Naylor, R.J.; Woodruff, G.N.
  • 5-HT 1A receptor agonists: recent developments and controversial issues
    De Vry, J.
  • The behavioural properties of CI-988, a selective cholecystokinin B receptor antagonist
    Singh, L.; Field, M.J.; Hughes, J.
  • Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT 1A and 5-HT 1B agonists
    Sprouse, J.S.; Aghajanian, G.K.
  • Pentagastrin induced panic attacks: enhanced sensitivity in panic disorder patients
    van Megen, H.J.G.M.; den Boer, J.A.; Westenberg, H.G.M.
  • Effect of the selective serotonin reuptake inhibitor fluvoxamine on CCK-4 induced panic attacks
    van Megen, H.J.G.M.; Westenberg, H.G.M.; den Boer, J.A.; Slaap, B.; Scheepmakers, A.

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