•Amphetamine-type stimulants (ATS) were the most commonly reported illicit drugs used by our sample of transgender women in Cambodia.•ATS use was independently associated with urban residence, low education, involvement in transactional sex, inconsistent condom use, binge drinking, lack of social support regarding transgender identity, poor mental health, and adverse childhood experiences.•This study highlights a need for additional harm reduction strategies tailored to address ATS use, HIV risks, and mental health among transgender women.•Integration of HIV prevention and mental health interventions into harm reduction programs is important for their success.
International Journal of Drug Policy – Elsevier
Published: Dec 1, 2019
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