Presynaptic 5-HT 1A receptors mediate the effect of ipsapirone on punished responding in rats

Presynaptic 5-HT 1A receptors mediate the effect of ipsapirone on punished responding in rats The effect of ipsapirone, a partial agonist at 5-HT 1A receptors, and of idazepam on punished operant responding was studied in rats injected intracerebroventricularly with 150 μg 5,7-dihydroxytryptamine to deplete brain serotonin or pretreated with ( S )-WAY 100135 ( N -tert-butyl 3-4-(2-methoxyphenyl)piperazin-1-yl-2-phenylpropanamide dihydrochloride), an antagonist at 5-HT 1A receptors. 5,7-Dihydroxytryptamine markedly depleted brain serotonin and caused a sustained increase in punished responding with no effect on rates of unpunished responding. Rates of punished responding returned to control values about 2 weeks after 5,7-dihydroxytryptamine. At doses ranging from 2.5 to 10 mg/kg s.c. ipsapirone significantly increased the rates of punished responding in sham-operated rats but had no effect in animals which had received 5,7-dihydroxytryptamine. At 5 and 10 mg/kg ipsapirone reduced unpunished responding similarly in sham-operated and 5,7-dihydroxytryptamine-treated rats. Diazepam 2.5 mg/kg i.p. significantly increased punished responding and reduced rates of unpunished responding similarly in sham-operated and in 5,7-dihydroxytryptamine-treated animals. At 3 and 10 mg/kg ( S )-WAY 100135 did not modify punished or unpunished responding but at 10 mg/kg it completely antagonized the effect of 5 mg/kg s.c. ipsapirone on unpunished and punished responding. The results suggest that ipsapirone releases behaviour that is suppressed by punishment by stimulating presynaptic 5-HT 1A receptors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

Presynaptic 5-HT 1A receptors mediate the effect of ipsapirone on punished responding in rats

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Ltd
ISSN
0014-2999
DOI
10.1016/0014-2999(95)00337-K
Publisher site
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Abstract

The effect of ipsapirone, a partial agonist at 5-HT 1A receptors, and of idazepam on punished operant responding was studied in rats injected intracerebroventricularly with 150 μg 5,7-dihydroxytryptamine to deplete brain serotonin or pretreated with ( S )-WAY 100135 ( N -tert-butyl 3-4-(2-methoxyphenyl)piperazin-1-yl-2-phenylpropanamide dihydrochloride), an antagonist at 5-HT 1A receptors. 5,7-Dihydroxytryptamine markedly depleted brain serotonin and caused a sustained increase in punished responding with no effect on rates of unpunished responding. Rates of punished responding returned to control values about 2 weeks after 5,7-dihydroxytryptamine. At doses ranging from 2.5 to 10 mg/kg s.c. ipsapirone significantly increased the rates of punished responding in sham-operated rats but had no effect in animals which had received 5,7-dihydroxytryptamine. At 5 and 10 mg/kg ipsapirone reduced unpunished responding similarly in sham-operated and 5,7-dihydroxytryptamine-treated rats. Diazepam 2.5 mg/kg i.p. significantly increased punished responding and reduced rates of unpunished responding similarly in sham-operated and in 5,7-dihydroxytryptamine-treated animals. At 3 and 10 mg/kg ( S )-WAY 100135 did not modify punished or unpunished responding but at 10 mg/kg it completely antagonized the effect of 5 mg/kg s.c. ipsapirone on unpunished and punished responding. The results suggest that ipsapirone releases behaviour that is suppressed by punishment by stimulating presynaptic 5-HT 1A receptors.

Journal

European Journal of PharmacologyElsevier

Published: Sep 25, 1995

References

  • Potential anxiolytic properties of 8-hydroxy-2-(di- n -propylamino)tetralin, a selective serotonin 1A receptor agonist
    Carli, M.; Samanin, R.
  • Evidence that central 5-hydroxytryptaminergic neurones are involved in the anxiolytic activity of buspirone
    Carli, M.; Prontera, C.; Samanin, R.
  • Low doses of the putative serotonin agonist 8-hydroxy-2-(di- n -propylamino)tetralin (8-OH-DPAT) elicit feeding
    Dourish, C.T.; Hutson, P.H.; Curzon, G.
  • Evidence that 5-HT 2C receptor antagonists are anxiolytic in the rat Geller-Seifter model of anxiety
    Kennett, G.A.; Pittaway, K.; Blackburn, T.P.
  • Stimulation of postsynaptic 5-HT 1A receptors is responsible for the anticonflict effect of ipsapirone in rats
    Przegalinski, E.; Chojnacka-Wojcik, E.; Filip, M.

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