Drug Discovery Today Volume 23, Number 3 March 2018 REVIEWS Teaser The key points emerging from the different drug-likeness rules and metrics allows scientifics working in the drug discovery domain to develop new medicines for the 21th century is provided in this original review. Based on the analyze of these descriptors, a simple strategy to prioritize the best drug-like compounds is also described. Present drug-likeness filters in medicinal chemistry during the hit and lead optimization process: how far can they be simplified? Serge Mignani received 1,2,3 2,4 2 Serge Mignani , João Rodrigues , Helena Tomas , his PhD from the Catholic 5 3 6,7 University of Louvain-la- Rachid Jalal , Parvinder Pal Singh , Jean-Pierre Majoral Neuve, Belgium under H.G. 3 Viehe and went on to and Ram A. Vishwakarma postdoctoral research at the University of Madison, USA with B.M. Trost. In Université Paris Descartes, PRES Sorbonne Paris Cité, CNRS UMR 860, Laboratoire de Chimie et de Biochimie 1981, he joined Rh˛ne- Pharmacologiques et Toxicologique, 45, Rue des Saints Peres, 75006 Paris, France 2 Poulenc (currently Sanoﬁ) at the Vitry Research CQM – Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9020-105 Center (France),
Drug Discovery Today – Elsevier
Published: Mar 1, 2018
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