Article history: To improve the skin permeation of naproxen with larger dosage, microemulsion with high content Received 12 November 2011 of naproxen was investigated for transdermal delivery and its solubilization mechanism was studied. Received in revised form Naproxen micoremulsions composed of 4% isopropyl myristate, 18% Tween 80, 18% ethanol and water 29 December 2011 were prepared and phase inversion temperature (PIT) method was used to increase drug content. The Accepted 9 January 2012 using of PIT method resulted in the maximum content of naproxen in microemulsion increased from Available online 16 January 2012 1.98 ± 0.13% to 4.12 ± 0.07%, accordingly the permeation rate of naproxen from microemulsion through −2 −1 excised mice skin increased from 135.13 ± 5.50 to 214.46 ± 7.53 g cm h . The analyses of Natural Keywords: Bond Orbital and interaction energy using the B3LYP and MP2 (fc) methods suggested that the solubi- Naproxen lization mechanism of microemulsion for naproxen mainly might be the formation of complex between Microemulsion the hydrogen atom of hydroxyl in Tween 80 and the oxygen atom of carbonyl group in naproxen, as is Solubilization Phase inversion temperature in accordance with the result from H NMR experiments. The change of
International Journal of Pharmaceutics – Elsevier
Published: Apr 15, 2012
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera