Article history: To improve the skin permeation of naproxen with larger dosage, microemulsion with high content Received 12 November 2011 of naproxen was investigated for transdermal delivery and its solubilization mechanism was studied. Received in revised form Naproxen micoremulsions composed of 4% isopropyl myristate, 18% Tween 80, 18% ethanol and water 29 December 2011 were prepared and phase inversion temperature (PIT) method was used to increase drug content. The Accepted 9 January 2012 using of PIT method resulted in the maximum content of naproxen in microemulsion increased from Available online 16 January 2012 1.98 ± 0.13% to 4.12 ± 0.07%, accordingly the permeation rate of naproxen from microemulsion through −2 −1 excised mice skin increased from 135.13 ± 5.50 to 214.46 ± 7.53 g cm h . The analyses of Natural Keywords: Bond Orbital and interaction energy using the B3LYP and MP2 (fc) methods suggested that the solubi- Naproxen lization mechanism of microemulsion for naproxen mainly might be the formation of complex between Microemulsion the hydrogen atom of hydroxyl in Tween 80 and the oxygen atom of carbonyl group in naproxen, as is Solubilization Phase inversion temperature in accordance with the result from H NMR experiments. The change of
International Journal of Pharmaceutics – Elsevier
Published: Apr 15, 2012
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