Article history: The objective of this study was to prepare different venlafaxine hydrochloride sustained-release products Received 3 July 2011 and to elucidate the inﬂuence of composition of the coating ﬁlm on the in vitro drug release proﬁles and Received in revised form 6 December 2011 in vivo pharmacokinetics. Pellets were prepared by a standardized process of extrusion/spheronization. Accepted 25 December 2011 A selected fraction size (0.8–1.0 mm diameter) of pellets of each formulation was coated with Eudragit Available online 14 January 2012 NE30D or ethylcellulose (10 cps). Many efforts have been made to tailor drug release rate by choosing different coating materials, different percent of pore forming components and coating weight variation Keywords: to achieve a desired sustained-release effect. The dissolution studies were performed and data were Venlafaxine analyzed in terms of cumulative release as a function of time. The inﬂuence on the release of venlafaxine Extrusion/spheronization ® from sustained-release capsules was observed in dissolution media of different pH and gradient pH. Eudragit NE30D Scanning electron microscope (SEM) micrographs revealed morphological changes of the pellet coating Ethylcellulose In vitro dissolution surface which were related to in vitro drug release proﬁles. The relative bioavailability for Formulation In vivo studies 1
International Journal of Pharmaceutics – Elsevier
Published: Apr 15, 2012
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera