Preparation and in vitro/in vivo evaluation of sustained-release venlafaxine hydrochloride pellets

Preparation and in vitro/in vivo evaluation of sustained-release venlafaxine hydrochloride pellets Article history: The objective of this study was to prepare different venlafaxine hydrochloride sustained-release products Received 3 July 2011 and to elucidate the influence of composition of the coating film on the in vitro drug release profiles and Received in revised form 6 December 2011 in vivo pharmacokinetics. Pellets were prepared by a standardized process of extrusion/spheronization. Accepted 25 December 2011 A selected fraction size (0.8–1.0 mm diameter) of pellets of each formulation was coated with Eudragit Available online 14 January 2012 NE30D or ethylcellulose (10 cps). Many efforts have been made to tailor drug release rate by choosing different coating materials, different percent of pore forming components and coating weight variation Keywords: to achieve a desired sustained-release effect. The dissolution studies were performed and data were Venlafaxine analyzed in terms of cumulative release as a function of time. The influence on the release of venlafaxine Extrusion/spheronization ® from sustained-release capsules was observed in dissolution media of different pH and gradient pH. Eudragit NE30D Scanning electron microscope (SEM) micrographs revealed morphological changes of the pellet coating Ethylcellulose In vitro dissolution surface which were related to in vitro drug release profiles. The relative bioavailability for Formulation In vivo studies 1 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Pharmaceutics Elsevier

Preparation and in vitro/in vivo evaluation of sustained-release venlafaxine hydrochloride pellets

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Publisher
Elsevier
Copyright
Copyright © 2011 Elsevier B.V.
ISSN
0378-5173
D.O.I.
10.1016/j.ijpharm.2011.12.053
Publisher site
See Article on Publisher Site

Abstract

Article history: The objective of this study was to prepare different venlafaxine hydrochloride sustained-release products Received 3 July 2011 and to elucidate the influence of composition of the coating film on the in vitro drug release profiles and Received in revised form 6 December 2011 in vivo pharmacokinetics. Pellets were prepared by a standardized process of extrusion/spheronization. Accepted 25 December 2011 A selected fraction size (0.8–1.0 mm diameter) of pellets of each formulation was coated with Eudragit Available online 14 January 2012 NE30D or ethylcellulose (10 cps). Many efforts have been made to tailor drug release rate by choosing different coating materials, different percent of pore forming components and coating weight variation Keywords: to achieve a desired sustained-release effect. The dissolution studies were performed and data were Venlafaxine analyzed in terms of cumulative release as a function of time. The influence on the release of venlafaxine Extrusion/spheronization ® from sustained-release capsules was observed in dissolution media of different pH and gradient pH. Eudragit NE30D Scanning electron microscope (SEM) micrographs revealed morphological changes of the pellet coating Ethylcellulose In vitro dissolution surface which were related to in vitro drug release profiles. The relative bioavailability for Formulation In vivo studies 1

Journal

International Journal of PharmaceuticsElsevier

Published: Apr 15, 2012

References

  • Modelling film-coat non-uniformity in polymer coated pellets: a stochastic approach
    Haddish-Berhane, N.; Jeong, S.H.; Haghighi, K.; Park, K.
  • Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
    Higuchi, T.
  • Drug release from hydrophilic matrices. 1. New scaling laws for predicting polymer and drug release based on the polymer disentanglement concentration and the diffusion layer
    Ju, R.T.; Nixon, P.R.; Patel, M.V.
  • Polymer blends for controlled release coatings
    Siepmann, F.; Siepmann, J.; Walther, M.; MacRae, R.J.; Bodmeier, R.

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