Objective: To determine the prevalence of antiphospholipid (aPL) and anti-beta 2 glycoprotein I (anti-β2-GPI) antibodies in women referred for IVF and to prospectively evaluate the effect of these antibodies on IVF outcome. Design: Prospective observational study. Setting: A university hospital and IVF unit. Patient(s): Three hundred eighty consecutive women referred for IVF. Intervention(s): Blood samples taken before commencement of IVF cycles were tested for the presence of aPL (lupus anticoagulant (LA), anticardiolipin (aCL), and antiphosphatidyl serine antibodies (aPS)) and anti-β2-GPI antibodies. Main Outcome Measure(s): Antibody prevalence, pregnancy rates, and live birth rates. Result(s): Of the total 380 women, 89 tested persistently positive for aPL (23.4%). None of 176 women tested for IgG aPS antibodies had a positive titer. Only 3.3% (11 of 329) tested positive for anti-β2-GPI antibodies. Pregnancy rate, live birth rate, gestational age at delivery, and birth weight were not affected by aPL status. Conclusion(s): Although women referred for IVF have a high prevalence of aPL, these antibodies do not affect the outcome of treatment. Screening women undergoing IVF for aPL is not justified.
Fertility and Sterility – Elsevier
Published: Mar 1, 2000
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