Pregnancy outcome is not affected by antiphospholipid antibody status in women referred for in vitro fertilization

Pregnancy outcome is not affected by antiphospholipid antibody status in women referred for in... Objective: To determine the prevalence of antiphospholipid (aPL) and anti-beta 2 glycoprotein I (anti-β2-GPI) antibodies in women referred for IVF and to prospectively evaluate the effect of these antibodies on IVF outcome. Design: Prospective observational study. Setting: A university hospital and IVF unit. Patient(s): Three hundred eighty consecutive women referred for IVF. Intervention(s): Blood samples taken before commencement of IVF cycles were tested for the presence of aPL (lupus anticoagulant (LA), anticardiolipin (aCL), and antiphosphatidyl serine antibodies (aPS)) and anti-β2-GPI antibodies. Main Outcome Measure(s): Antibody prevalence, pregnancy rates, and live birth rates. Result(s): Of the total 380 women, 89 tested persistently positive for aPL (23.4%). None of 176 women tested for IgG aPS antibodies had a positive titer. Only 3.3% (11 of 329) tested positive for anti-β2-GPI antibodies. Pregnancy rate, live birth rate, gestational age at delivery, and birth weight were not affected by aPL status. Conclusion(s): Although women referred for IVF have a high prevalence of aPL, these antibodies do not affect the outcome of treatment. Screening women undergoing IVF for aPL is not justified. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Fertility and Sterility Elsevier

Pregnancy outcome is not affected by antiphospholipid antibody status in women referred for in vitro fertilization

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Publisher
Elsevier
Copyright
Copyright © 2000 American Society for Reproductive Medicine
ISSN
0015-0282
DOI
10.1016/S0015-0282(99)00585-3
Publisher site
See Article on Publisher Site

Abstract

Objective: To determine the prevalence of antiphospholipid (aPL) and anti-beta 2 glycoprotein I (anti-β2-GPI) antibodies in women referred for IVF and to prospectively evaluate the effect of these antibodies on IVF outcome. Design: Prospective observational study. Setting: A university hospital and IVF unit. Patient(s): Three hundred eighty consecutive women referred for IVF. Intervention(s): Blood samples taken before commencement of IVF cycles were tested for the presence of aPL (lupus anticoagulant (LA), anticardiolipin (aCL), and antiphosphatidyl serine antibodies (aPS)) and anti-β2-GPI antibodies. Main Outcome Measure(s): Antibody prevalence, pregnancy rates, and live birth rates. Result(s): Of the total 380 women, 89 tested persistently positive for aPL (23.4%). None of 176 women tested for IgG aPS antibodies had a positive titer. Only 3.3% (11 of 329) tested positive for anti-β2-GPI antibodies. Pregnancy rate, live birth rate, gestational age at delivery, and birth weight were not affected by aPL status. Conclusion(s): Although women referred for IVF have a high prevalence of aPL, these antibodies do not affect the outcome of treatment. Screening women undergoing IVF for aPL is not justified.

Journal

Fertility and SterilityElsevier

Published: Mar 1, 2000

References

  • Incidence of autoimmune antibodies in failed embryo transfer cycles
    Birkenfeld, A; Mukaida, T; Minichiello, L; Jackson, M; Kase, N.G; Yemini, M
  • Antiphospholipid antibodies and pregnancy rates and outcome in in vitro fertilization patients
    Denis, A.L; Guido, M; Adler, R.D; Bergh, P.A; Brenner, C; Scott, R.T
  • Antiphospholipid antibody prevalence in patients with IVF failure
    Kaider, B.D; Price, D.E; Roussev, R.G; Coulam, C.B
  • The reproductive autoimmune failure syndrome
    Gleicher, N; el-Roeiy, A

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