Pre-trial cocaine biases choice toward cocaine through suppression of the nondrug option

Pre-trial cocaine biases choice toward cocaine through suppression of the nondrug option Being under the influence during choice between drug and nondrug options can have a dramatic effect on choice outcomes. When rats face a choice between cocaine and sweet water and are not under the influence, they prefer sweet water. In contrast, when they are under the influence of cocaine, this causes them to shift their choice to cocaine nearly exclusively. Here we sought to characterize the behavioral mechanisms underlying the influence of cocaine on choice. In theory, rats under the influence of cocaine should be in a mixed motivational state, at least temporarily, with both their motivation for cocaine and their motivation for the nondrug option suppressed by the drug satiating and anorexic effects of cocaine, respectively. For this mixed state to shift choice to cocaine, the satiated motivation for cocaine should recover before the suppressed motivation for the preferred nondrug option. The goal of the present study was to test this prediction in rats that expressed a preference for sweet water after extended access to cocaine self-administration. We measured their choice and response latencies to each option after pre-trial, passive administration of cocaine to estimate the duration of its drug satiating and anorexic effects. As expected, pre-trial cocaine caused most rats to shift their choice to cocaine. Though this shift was not simply due to a longer latency to respond for sweet water than for cocaine after pre-trial cocaine, it nevertheless occurred while rats' motivation for the nondrug option was still partially suppressed. Thus, cocaine seems to bias choice toward more cocaine mainly via suppression of the nondrug option. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmacology Biochemistry and Behavior Elsevier

Pre-trial cocaine biases choice toward cocaine through suppression of the nondrug option

Loading next page...
 
/lp/elsevier/pre-trial-cocaine-biases-choice-toward-cocaine-through-suppression-of-cbBCSPsgI2
Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Inc.
ISSN
0091-3057
eISSN
1873-5177
D.O.I.
10.1016/j.pbb.2018.07.010
Publisher site
See Article on Publisher Site

Abstract

Being under the influence during choice between drug and nondrug options can have a dramatic effect on choice outcomes. When rats face a choice between cocaine and sweet water and are not under the influence, they prefer sweet water. In contrast, when they are under the influence of cocaine, this causes them to shift their choice to cocaine nearly exclusively. Here we sought to characterize the behavioral mechanisms underlying the influence of cocaine on choice. In theory, rats under the influence of cocaine should be in a mixed motivational state, at least temporarily, with both their motivation for cocaine and their motivation for the nondrug option suppressed by the drug satiating and anorexic effects of cocaine, respectively. For this mixed state to shift choice to cocaine, the satiated motivation for cocaine should recover before the suppressed motivation for the preferred nondrug option. The goal of the present study was to test this prediction in rats that expressed a preference for sweet water after extended access to cocaine self-administration. We measured their choice and response latencies to each option after pre-trial, passive administration of cocaine to estimate the duration of its drug satiating and anorexic effects. As expected, pre-trial cocaine caused most rats to shift their choice to cocaine. Though this shift was not simply due to a longer latency to respond for sweet water than for cocaine after pre-trial cocaine, it nevertheless occurred while rats' motivation for the nondrug option was still partially suppressed. Thus, cocaine seems to bias choice toward more cocaine mainly via suppression of the nondrug option.

Journal

Pharmacology Biochemistry and BehaviorElsevier

Published: Oct 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off