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leukocyte cultures (Pestka et al., 1994; Poapolathep et al., 2004; Uzarski and Pestka, 2003). Trichothecene - induced apoptosis in vitro is dependent on p38 and JNK activation, but can be downregulated by ERK ...
Abstract Deoxynivalenol (DON) and other ribotoxic trichothecenes cause immune stimulation and suppression in leukocytes by upregulating gene expression and apoptosis, respectively. The purpose ...
, and cytotoxicity in the upper and lower respiratory tracts. Macrocyclic trichothecene mycotoxins, produced by one chemotype of this fungus, are potent translational inhibitors and stress kinase activators ...
and Zhou, 2000), antibody neutralization (Yan et al., 1997), and ex vivo cultures (Yan et al., 1998). In addition, exposure to lipopolysaccharide potentiates DON- induced inflammation and cytotoxicity ...
Abstract Macrocyclic trichothecene mycotoxins produced by indoor air molds potentially contribute to symptoms associated with damp building illnesses. The purpose of this investigation ...
., trichodermol and trichodermin). In vitro studies have revealed that the macrocyclic trichothecene producing isolates are highly cytotoxic while the atranone producers are associated with induction of strong ...
pathways involving ERK and p38. Interestingly, trichothecenes are also thought to induce leukocyte apoptosis via the p38 and JNK signaling pathways (Shifrin et al., 1999; Yang et al., 2000). The VT ...
Abstract The trichothecene mycotoxin deoxynivalenol (DON) induces systemic expression of the interleukin-6 (IL-6) and other proinflammatory cytokines in the mouse. The purpose of this study ...
expressions of proinflammatory cytokines induced by trichothecenes . Interestingly, the time when the mRNA levels of STAT1 and STAT3 were significantly upregulated was at 12 h, which was much later than the time ...
phosphorylation in spleen and Peyer's patches of mice (Moon and Pestka, 2003; Zhou et al., 2003a) as well as in leukocyte cultures (Shifrin and Anderson, 1999; Yang et al., 2000). Trichothecene - induced p38 and ERK1 ...
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