Potentiation of penile erection and yawning responses to apomorphine by cannabinoid receptor antagonist in rats

Potentiation of penile erection and yawning responses to apomorphine by cannabinoid receptor... The effect of systemic administration of the cannabinoid antagonist SR 141716A ( N -(piperidin-1-yl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxyamide) on penile erection and yawning induced by apomorphine was investigated in rats. SR 141716A (2 mg/kg, i.p.) administered 40 min before apomorphine (40 and 80 μg/kg, s.c.) increased the number of penile erection and yawning responses. The administration of cannabinoid agonist Δ 9 -tetrahydrocannabinol (1.25 mg/kg, i.p.) 15 min before apomorphine (40 and 80 μg/kg, s.c.) did not affect penile erection, however it decreased yawning. The present results provide additional evidence that cannabinoid agonists interfere with dopaminergic systems and that SR 141716A together with a dopaminergic agonist could be useful to potentiate dopaminergic activity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroscience Letters Elsevier

Potentiation of penile erection and yawning responses to apomorphine by cannabinoid receptor antagonist in rats

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Publisher
Elsevier
Copyright
Copyright © 2003 Elsevier Ireland Ltd
ISSN
0304-3940
D.O.I.
10.1016/S0304-3940(03)00782-1
Publisher site
See Article on Publisher Site

Abstract

The effect of systemic administration of the cannabinoid antagonist SR 141716A ( N -(piperidin-1-yl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxyamide) on penile erection and yawning induced by apomorphine was investigated in rats. SR 141716A (2 mg/kg, i.p.) administered 40 min before apomorphine (40 and 80 μg/kg, s.c.) increased the number of penile erection and yawning responses. The administration of cannabinoid agonist Δ 9 -tetrahydrocannabinol (1.25 mg/kg, i.p.) 15 min before apomorphine (40 and 80 μg/kg, s.c.) did not affect penile erection, however it decreased yawning. The present results provide additional evidence that cannabinoid agonists interfere with dopaminergic systems and that SR 141716A together with a dopaminergic agonist could be useful to potentiate dopaminergic activity.

Journal

Neuroscience LettersElsevier

Published: Sep 25, 2003

References

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