Potential Role of Nitric Oxide and Endothelin in the Pathogenesis of Glaucoma

Potential Role of Nitric Oxide and Endothelin in the Pathogenesis of Glaucoma Glaucoma is an optic nerve head neuropathy in which retinal ganglion cells are lost. A clear association exists between glaucoma and different risk factors, such as high intraocular pressure (IOP) or blood-flow dysregulation. Nitric oxide (NO) and endothelin, two recently identified cellular mediators, appear to be involved in the regulation of IOP as well as in the modulation of ocular blood flow. To some extent, NO is also involved in apoptosis, a mechanism of cell death that can lead to retinal ganglion cell loss in glaucoma. This article provides a short and simplified overview of the biochemistry of NO and endothelin and highlights the potential role of these two mediators in certain important aspects related to the pathogenesis of glaucoma. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Survey of Ophthalmology Elsevier

Potential Role of Nitric Oxide and Endothelin in the Pathogenesis of Glaucoma

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Publisher
Elsevier
Copyright
Copyright © 1999 Elsevier Science Inc.
ISSN
0039-6257
D.O.I.
10.1016/S0039-6257(99)00026-0
Publisher site
See Article on Publisher Site

Abstract

Glaucoma is an optic nerve head neuropathy in which retinal ganglion cells are lost. A clear association exists between glaucoma and different risk factors, such as high intraocular pressure (IOP) or blood-flow dysregulation. Nitric oxide (NO) and endothelin, two recently identified cellular mediators, appear to be involved in the regulation of IOP as well as in the modulation of ocular blood flow. To some extent, NO is also involved in apoptosis, a mechanism of cell death that can lead to retinal ganglion cell loss in glaucoma. This article provides a short and simplified overview of the biochemistry of NO and endothelin and highlights the potential role of these two mediators in certain important aspects related to the pathogenesis of glaucoma.

Journal

Survey of OphthalmologyElsevier

Published: Jun 1, 1999

References

  • multifaceted roles and diverse outcome
    Becquet, F.; Courtois, Y.; Goureau, O.; Nitric oxide in the eye
  • Nitric oxide, a novel neuronal messenger
    Bredt, D.S.; Snyder, S.H.
  • Nitric oxide and its role in apoptosis
    Brune, B.; von Knethen, A.; Sandau, K.B.
  • The role of nitric oxide and other endothelium-derived vasoactive substances in vascular disease
    Cohen, R.A.
  • Optic nerve blood-flow abnormalities in glaucoma
    Flammer, J.; Orgul, S.
  • Molecular biology of nitric oxide synthases
    Geller, D.A.; Billiar, T.R.
  • Nitric oxide and endothelin in the pathogenesis of glaucoma
    Haefliger, I.O.; Dettmann, E.S.
  • Dual actions of nitric oxide in N-methyl-D-aspartate receptor-mediated neurotoxicity in cultured retinal neurons
    Kashii, S.; Mandai, M.; Kikuchi, M.
  • Role of nitric oxide in the control of apoptosis in the microvasculature
    Lopez-Farre, A.; Rodriguez-Feo, J.A.; Sanchez de Miguel, L.
  • Vascular pathogenesis of normal-tension glaucoma
    Yamamoto, T.; Kitazawa, Y.

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