Potential role for Ginkgo biloba extract in the treatment of glaucoma

Potential role for Ginkgo biloba extract in the treatment of glaucoma Glaucoma is becoming recognized as a condition for which not only elevated intraocular pressure, but also non-pressure-dependent risk factors are responsible. New avenues of treatment into which investigations are being initiated include agents which could possibly improve blood flow to the eye and neuroprotective drugs. Only calcium channel blockers are presently available for such treatment in glaucoma, and these have not been widely adopted, in contrast to clinical trials involving a number of neuroprotectants in other neurologic disorders. Ginkgo biloba extract is freely available and has several biological actions which combine to make it a potentially important agent in the treatment of glaucoma: improvement of central and peripheral blood flow, reduction of vasospasm, reduction of serum viscosity, antioxidant activity, platelet activating factor inhibitory activity, inhibition of apoptosis, and inhibition of excitotoxicity. The effect of Ginkgo biloba extract as a potential antiglaucoma therapy deserves intensive scrutiny. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Medical Hypotheses Elsevier

Potential role for Ginkgo biloba extract in the treatment of glaucoma

Medical Hypotheses, Volume 54 (2) – Feb 1, 2000

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Publisher
Elsevier
Copyright
Copyright © 2000 Harcourt Publishers Ltd
ISSN
0306-9877
eISSN
1532-2777
D.O.I.
10.1054/mehy.1999.0025
Publisher site
See Article on Publisher Site

Abstract

Glaucoma is becoming recognized as a condition for which not only elevated intraocular pressure, but also non-pressure-dependent risk factors are responsible. New avenues of treatment into which investigations are being initiated include agents which could possibly improve blood flow to the eye and neuroprotective drugs. Only calcium channel blockers are presently available for such treatment in glaucoma, and these have not been widely adopted, in contrast to clinical trials involving a number of neuroprotectants in other neurologic disorders. Ginkgo biloba extract is freely available and has several biological actions which combine to make it a potentially important agent in the treatment of glaucoma: improvement of central and peripheral blood flow, reduction of vasospasm, reduction of serum viscosity, antioxidant activity, platelet activating factor inhibitory activity, inhibition of apoptosis, and inhibition of excitotoxicity. The effect of Ginkgo biloba extract as a potential antiglaucoma therapy deserves intensive scrutiny.

Journal

Medical HypothesesElsevier

Published: Feb 1, 2000

References

  • Anti-Ro/SS-A positivity and heat shock protein antibodies in patients with normal-pressure glaucoma
    Wax, M.B.; Tezel, G.; Saito, I.
  • Excitotoxicity, free radicals, and cell membrane changes
    Dugan, L.L.; Choi, D.W.
  • Potential neuroprotective therapy for glaucomatous optic neuropathy
    Yoles, E.; Schwartz, M.
  • Effect of the antioxidant action of ginkgo biloba extract (EGb 761) on aging and oxidative stress
    Droy-Lefaix, M.T.
  • Extracts of Ginkgo biloba L. leaves and Vaccinium myrtillus L. fruits prevent photo induced oxidation of low density lipoprotein cholesterol
    Rasetti, M.F.; Caruso, D.; Galli, G.; Bosisio, E.
  • Preventive effect of Ginkgo biloba extract on apoptosis in rat cerebellar neuronal cells induced by hydroxyl radicals
    Ni, Y.C.; Zhao, B.L.; Hou, J.W.; Xin, W.J.
  • Antioxidative activity of ginkgolides against superoxide in an aprotic environment
    Scholtyssek, H.; Damerau, W.; Wessel, R.; Schimke, I.
  • Platelet-activating factor and related acetylated lipids as potent biologically active cellular mediators
    Snyder, F.
  • Platelet-activating factor antagonist BN52021 decreases accumulation of free polyunsaturated fatty acid in mouse brain during ischemia and electroconvulsive shock
    Birkle, D.L.; Kurian, P.; Braquet, P.; Bazan, N.G.
  • The effect of Ginkgo biloba glycoside on the blood viscosity and erythrocyte deformability
    Erdincler, D.S.; Karakoc, Y.; Toplan, S.
  • Phospholipid breakdown and choline release under hypoxic conditions: inhibition by bilobalide, a constituent of Ginkgo biloba
    Klein, J.; Chatterjee, S.S.; Löffelholz, K.
  • Extracts of Ginkgo biloba and ginsenosides exert cerebral vasorelaxation via a nitric oxide pathway
    Chen, X.; Salwinski, S.; Lee, T.J.F.
  • Effects of repeated treatments with an extract of Ginkgo biloba (EGb 761) and bilobalide on glucose uptake and glycogen synthesis in rat erythrocytes – an ex vivo study
    Rapin, J.R.; Provost, P.; DeFeudis, F.V.; Drieu, K.
  • Ginkgo biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide
    Oyama, Y.; Chikahisa, L.; Ueha, T.
  • Motor function in young and aged hemiplegic rats: Effects of a ginkgo biloba extract
    Brailowsky, S.; Montiel, T.
  • Nitric oxide deficiency, leukocyte activation, and resultant ischemia are crucial to the pathogenesis of diabetic retinopathy/neuropathy – preventive potential of antioxidants, essential fatty acids, chromium, ginkgolides, and pentoxifylline
    McCarty, M.F.
  • Ginkgo biloba for cerebral insufficiency
    Kleijnen, J.; Knipschild, P.
  • Anxiolytic-like effect of combined extracts of Zingiber officinale and ginkgo biloba in the elevated plus-maze
    Hasenöhrl, R.U.; Nichau, C.H.; Frisch, C.H.
  • Blockade of lithium chloride-induced conditioned place aversion as a test for antiemetic agents: comparison of metoclopramide with combined extracts of Zingiber officinale and Ginkgo biloba
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  • Chemistry and biology of alkylphenols from Ginkgo biloba L.
    Jaggy, H.; Koch, E.
  • Apoptosis: a new pharmacodynamic endpoint
    Au, J.L.S.; Panchal, N.; Li, D.; Gan, Y.

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