Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Postmenopausal changes in serum cytokine levels and hormone replacement therapy

Postmenopausal changes in serum cytokine levels and hormone replacement therapy Objective: Our purpose was to investigate the effect of hormone replacement therapy on the postmenopausal changes in serum cytokine levels. Study Design: Fifteen cytokines were measured by an enzyme-linked immunosorbent assay in 97 untreated and hormone replacement–treated women. Thirteen women were examined before and during hormone replacement therapy. Results: Serum concentrations of macrophage colony-stimulating factor were significantly ( P < .05) lower during the early postmenopausal period (≤10 years) than the values in premenopause and the elevated levels in the late postmenopausal period (≤30 years). A significant increase in tumor necrosis factor α and a decline in transforming growth factor β1 were found in late postmenopausal women. Serum levels of macrophage colony-stimulating factor in women receiving hormone replacement therapy were significantly higher than those in untreated postmenopausal women. Furthermore, hormone replacement therapy induced a significant ( P < .01) increase in serum levels of macrophage colony-stimulating factor, whereas serum levels of other cytokines were not affected. Conclusion: It is well documented that macrophage colony-stimulating factor lowers serum cholesterol concentrations and prevents atherosclerosis. Inducing the production of macrophage colony-stimulating factor is a possible additional mechanism of hormone replacement therapy in mediating the antiatherogenic effect. (Am J Obstet Gynecol 2001;184:309-14.) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Obstetrics and Gynecology Wolters Kluwer Health

Postmenopausal changes in serum cytokine levels and hormone replacement therapy

Download PDF
6 pages

Loading next page...
 
/lp/elsevier/postmenopausal-changes-in-serum-cytokine-levels-and-hormone-9EDxs6HIeb

References (25)

Publisher
Wolters Kluwer Health
Copyright
Copyright © 2001 Academic Press
ISSN
0002-9378
DOI
10.1067/mob.2001.109940
pmid
11228479
Publisher site
See Article on Publisher Site

Abstract

Objective: Our purpose was to investigate the effect of hormone replacement therapy on the postmenopausal changes in serum cytokine levels. Study Design: Fifteen cytokines were measured by an enzyme-linked immunosorbent assay in 97 untreated and hormone replacement–treated women. Thirteen women were examined before and during hormone replacement therapy. Results: Serum concentrations of macrophage colony-stimulating factor were significantly ( P < .05) lower during the early postmenopausal period (≤10 years) than the values in premenopause and the elevated levels in the late postmenopausal period (≤30 years). A significant increase in tumor necrosis factor α and a decline in transforming growth factor β1 were found in late postmenopausal women. Serum levels of macrophage colony-stimulating factor in women receiving hormone replacement therapy were significantly higher than those in untreated postmenopausal women. Furthermore, hormone replacement therapy induced a significant ( P < .01) increase in serum levels of macrophage colony-stimulating factor, whereas serum levels of other cytokines were not affected. Conclusion: It is well documented that macrophage colony-stimulating factor lowers serum cholesterol concentrations and prevents atherosclerosis. Inducing the production of macrophage colony-stimulating factor is a possible additional mechanism of hormone replacement therapy in mediating the antiatherogenic effect. (Am J Obstet Gynecol 2001;184:309-14.)

Journal

American Journal of Obstetrics and Gynecology – Wolters Kluwer Health

Published: Feb 1, 2001

There are no references for this article.