Post-transcriptional gene silencing by siRNAs and miRNAs

Post-transcriptional gene silencing by siRNAs and miRNAs Recent years have seen a rapid increase in our understanding of how double-stranded RNA (dsRNA) and 21- to 25-nucleotide small RNAs, microRNAs (miRNAs) and small interfering RNAs (siRNAs), control gene expression in eukaryotes. This RNA-mediated regulation generally results in sequence-specific inhibition of gene expression; this can occur at levels as different as chromatin modification and silencing, translational repression and mRNA degradation. Many details of the biogenesis and function of miRNAs and siRNAs, and of the effector complexes with which they associate have been elucidated. The first structural information on protein components of the RNA interference (RNAi) and miRNA machineries is emerging, and provides some insight into the mechanism of RNA-silencing reactions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Structural Biology Elsevier

Post-transcriptional gene silencing by siRNAs and miRNAs

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Publisher
Elsevier
Copyright
Copyright © 2005 Elsevier Ltd
ISSN
0959-440x
D.O.I.
10.1016/j.sbi.2005.05.006
Publisher site
See Article on Publisher Site

Abstract

Recent years have seen a rapid increase in our understanding of how double-stranded RNA (dsRNA) and 21- to 25-nucleotide small RNAs, microRNAs (miRNAs) and small interfering RNAs (siRNAs), control gene expression in eukaryotes. This RNA-mediated regulation generally results in sequence-specific inhibition of gene expression; this can occur at levels as different as chromatin modification and silencing, translational repression and mRNA degradation. Many details of the biogenesis and function of miRNAs and siRNAs, and of the effector complexes with which they associate have been elucidated. The first structural information on protein components of the RNA interference (RNAi) and miRNA machineries is emerging, and provides some insight into the mechanism of RNA-silencing reactions.

Journal

Current Opinion in Structural BiologyElsevier

Published: Jun 1, 2005

References

  • The human DiGeorge syndrome critical region gene 8 and its D . melanogaster homolog are required for miRNA biogenesis
    Landthaler, M.; Yalcin, A.; Tuschl, T.
  • Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP
    Zhang, H.; Kolb, F.A.; Brondani, V.; Billy, E.; Filipowicz, W.
  • Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors
    Doi, N.; Zenno, S.; Ueda, R.; Ohki-Hamazaki, H.; Ui-Tei, K.; Saigo, K.
  • Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer
    Tahbaz, N.; Kolb, F.A.; Zhang, H.; Jaronczyk, K.; Filipowicz, W.; Hobman, T.C.
  • Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity
    Parker, J.S.; Roe, S.M.; Barford, D.
  • The RNA-induced silencing complex is a Mg 2+ -dependent endonuclease
    Schwarz, D.S.; Tomari, Y.; Zamore, P.D.
  • The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation
    Olsen, P.H.; Ambros, V.
  • Loss of the putative RNA-directed RNA polymerase RRF-3 makes C . elegans hypersensitive to RNAi
    Simmer, F.; Tijsterman, M.; Parrish, S.; Koushika, S.P.; Nonet, M.L.; Fire, A.; Ahringer, J.; Plasterk, R.H.
  • MicroRNAs and other tiny endogenous RNAs in C. elegans
    Ambros, V.; Lee, R.C.; Lavanway, A.; Williams, P.T.; Jewell, D.

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