Post-blast treatment with Nociceptin/Orphanin FQ peptide (NOP) receptor antagonist reduces brain injury-induced hypoxia and signaling proteins in vestibulomotor-related brain regions

Post-blast treatment with Nociceptin/Orphanin FQ peptide (NOP) receptor antagonist reduces brain... Article history: Mild traumatic brain injury (mTBI) diagnoses have increased due to aggressive sports and blast-related Received 31 August 2016 injuries, but the cellular mechanisms and pathology underlying mTBI are not completely understood. Received in revised form 17 October 2016 Previous reports indicate that Nociceptin Orphanin/FQ (N/OFQ), an endogenous neuropeptide, con- Accepted 24 October 2016 tributes to post-injury ischemia following mechanical brain injury, yet its specific role in cerebral Available online 25 October 2016 hypoxia, vestibulomotor function and injury marker expression following blast-induced TBI is not known. This study is the first to identify a direct association of N/OFQ and its N/OFQ peptide (NOP) Keywords: receptor with TBI-induced changes following a single 80 psi head blast exposure in male rats. N/OFQ Nociceptin/Orphanin FQ peptide receptor and NOP receptor expression increased in brain tissue and plasma following TBI, concurrent with Blast traumatic brain injury vestibular dysfunction but preceding hypoxia and appearance of injury markers compared to sham rats. Corresponding author at: Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, 1110 N. Stonewall Avenue, Suite 315, Oklahoma City, OK 73117, USA. E-mail address: hawwad@ouhsc.edu (H.O. Awwad). https://doi.org/10.1016/j.bbr.2016.10.041 0166-4328/© 2016 Elsevier B.V. All rights reserved. 184 H.O. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Behavioural Brain Research Elsevier

Post-blast treatment with Nociceptin/Orphanin FQ peptide (NOP) receptor antagonist reduces brain injury-induced hypoxia and signaling proteins in vestibulomotor-related brain regions

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Publisher
Elsevier
Copyright
Copyright © 2016 Elsevier B.V.
ISSN
0166-4328
D.O.I.
10.1016/j.bbr.2016.10.041
Publisher site
See Article on Publisher Site

Abstract

Article history: Mild traumatic brain injury (mTBI) diagnoses have increased due to aggressive sports and blast-related Received 31 August 2016 injuries, but the cellular mechanisms and pathology underlying mTBI are not completely understood. Received in revised form 17 October 2016 Previous reports indicate that Nociceptin Orphanin/FQ (N/OFQ), an endogenous neuropeptide, con- Accepted 24 October 2016 tributes to post-injury ischemia following mechanical brain injury, yet its specific role in cerebral Available online 25 October 2016 hypoxia, vestibulomotor function and injury marker expression following blast-induced TBI is not known. This study is the first to identify a direct association of N/OFQ and its N/OFQ peptide (NOP) Keywords: receptor with TBI-induced changes following a single 80 psi head blast exposure in male rats. N/OFQ Nociceptin/Orphanin FQ peptide receptor and NOP receptor expression increased in brain tissue and plasma following TBI, concurrent with Blast traumatic brain injury vestibular dysfunction but preceding hypoxia and appearance of injury markers compared to sham rats. Corresponding author at: Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, 1110 N. Stonewall Avenue, Suite 315, Oklahoma City, OK 73117, USA. E-mail address: hawwad@ouhsc.edu (H.O. Awwad). https://doi.org/10.1016/j.bbr.2016.10.041 0166-4328/© 2016 Elsevier B.V. All rights reserved. 184 H.O.

Journal

Behavioural Brain ResearchElsevier

Published: Mar 15, 2018

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