Positive reinforcing effects of flupirtine — Two case reports

Positive reinforcing effects of flupirtine — Two case reports To the Editor Flupirtine is currently in clinical use because of its analgesic properties. It is thought to act by functional N-methyl- d -aspartic acid (NMDA) receptor antagonism via voltage-independent potassium channels Hummel et al. (1991) . In contrast to other studies ( Bisaga and Evans, 2004; Herrmann et al., 1987; Preston et al., 1991; Scheef, 1987 ) and animal studies ( Sofia et al., 1987 ) which report no or only moderate abuse liability of flupirtine, we present here two cases in which flupirtine treatment is associated with pleasurable and reinforcing effects.</P>1 <h5>Case report 1</h5> Mr. F., a 46-year-old man, who suffered from alcohol dependency according to ICD-10 criteria, was treated as an inpatient because of alcohol withdrawal syndrome. The patient's history was positive for former alcohol withdrawal episodes without severe complications. There was no history of other further psychiatric comorbidities and no other medication was taken. At admission to our ward, breath alcohol concentration was negative. The intensity of alcohol craving was continually measured during therapy using the Obsessive Compulsive Drinking Scale (OCDS). Total score of OCDS on day one of treatment was 20 points, which was divided into 5 points on the obsessive craving scale http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Progress in Neuro-Psychopharmacology & Biological Psychiatry Elsevier

Positive reinforcing effects of flupirtine — Two case reports

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Publisher
Elsevier
Copyright
Copyright © 2010 Elsevier Inc.
ISSN
0278-5846
eISSN
1878-4216
D.O.I.
10.1016/j.pnpbp.2010.03.031
Publisher site
See Article on Publisher Site

Abstract

To the Editor Flupirtine is currently in clinical use because of its analgesic properties. It is thought to act by functional N-methyl- d -aspartic acid (NMDA) receptor antagonism via voltage-independent potassium channels Hummel et al. (1991) . In contrast to other studies ( Bisaga and Evans, 2004; Herrmann et al., 1987; Preston et al., 1991; Scheef, 1987 ) and animal studies ( Sofia et al., 1987 ) which report no or only moderate abuse liability of flupirtine, we present here two cases in which flupirtine treatment is associated with pleasurable and reinforcing effects.</P>1 <h5>Case report 1</h5> Mr. F., a 46-year-old man, who suffered from alcohol dependency according to ICD-10 criteria, was treated as an inpatient because of alcohol withdrawal syndrome. The patient's history was positive for former alcohol withdrawal episodes without severe complications. There was no history of other further psychiatric comorbidities and no other medication was taken. At admission to our ward, breath alcohol concentration was negative. The intensity of alcohol craving was continually measured during therapy using the Obsessive Compulsive Drinking Scale (OCDS). Total score of OCDS on day one of treatment was 20 points, which was divided into 5 points on the obsessive craving scale

Journal

Progress in Neuro-Psychopharmacology & Biological PsychiatryElsevier

Published: Aug 16, 2010

References

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