To the Editor Flupirtine is currently in clinical use because of its analgesic properties. It is thought to act by functional N-methyl- d -aspartic acid (NMDA) receptor antagonism via voltage-independent potassium channels Hummel et al. (1991) . In contrast to other studies ( Bisaga and Evans, 2004; Herrmann et al., 1987; Preston et al., 1991; Scheef, 1987 ) and animal studies ( Sofia et al., 1987 ) which report no or only moderate abuse liability of flupirtine, we present here two cases in which flupirtine treatment is associated with pleasurable and reinforcing effects.</P>1 <h5>Case report 1</h5> Mr. F., a 46-year-old man, who suffered from alcohol dependency according to ICD-10 criteria, was treated as an inpatient because of alcohol withdrawal syndrome. The patient's history was positive for former alcohol withdrawal episodes without severe complications. There was no history of other further psychiatric comorbidities and no other medication was taken. At admission to our ward, breath alcohol concentration was negative. The intensity of alcohol craving was continually measured during therapy using the Obsessive Compulsive Drinking Scale (OCDS). Total score of OCDS on day one of treatment was 20 points, which was divided into 5 points on the obsessive craving scale
Progress in Neuro-Psychopharmacology & Biological Psychiatry – Elsevier
Published: Aug 16, 2010
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