•A high prevalence of resistance-associated substitutions (RASs) was detected in HCV-1 from Argentinean naïve patients.•The prevalence of RASs was higher in HCV-1b than in HCV-1a.•A great prevalence of double mutants (17.2%) was detected in HCV-1b but not in HCV-1a.•Q80K polymorphism was not detected in patients carrying HCV-1a, even in patients belonging to clade 1.•The phylogenetic analysis showed that Argentinean samples were distributed randomly among sequences around the world.
Virus Research – Elsevier
Published: Aug 15, 2017
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