Polymorphisms associated with resistance to protease inhibitors in naïve patients infected with hepatitis C virus genotype 1 in Argentina: Low prevalence of Q80K

Polymorphisms associated with resistance to protease inhibitors in naïve patients infected with... •A high prevalence of resistance-associated substitutions (RASs) was detected in HCV-1 from Argentinean naïve patients.•The prevalence of RASs was higher in HCV-1b than in HCV-1a.•A great prevalence of double mutants (17.2%) was detected in HCV-1b but not in HCV-1a.•Q80K polymorphism was not detected in patients carrying HCV-1a, even in patients belonging to clade 1.•The phylogenetic analysis showed that Argentinean samples were distributed randomly among sequences around the world. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Virus Research Elsevier

Polymorphisms associated with resistance to protease inhibitors in naïve patients infected with hepatitis C virus genotype 1 in Argentina: Low prevalence of Q80K

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier B.V.
ISSN
0168-1702
D.O.I.
10.1016/j.virusres.2017.08.006
Publisher site
See Article on Publisher Site

Abstract

•A high prevalence of resistance-associated substitutions (RASs) was detected in HCV-1 from Argentinean naïve patients.•The prevalence of RASs was higher in HCV-1b than in HCV-1a.•A great prevalence of double mutants (17.2%) was detected in HCV-1b but not in HCV-1a.•Q80K polymorphism was not detected in patients carrying HCV-1a, even in patients belonging to clade 1.•The phylogenetic analysis showed that Argentinean samples were distributed randomly among sequences around the world.

Journal

Virus ResearchElsevier

Published: Aug 15, 2017

References

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