Polymorphic miRNA-mediated gene regulation: contribution to phenotypic variation and disease

Polymorphic miRNA-mediated gene regulation: contribution to phenotypic variation and disease The expression of at least a third of mammalian genes is post-transcriptionally fine-tuned by ∼1000 microRNAs (miRNAs), assisted by the RNA silencing machinery, comprising tens of components. Polymorphisms and mutations in the corresponding sequence space (machinery, miRNA precursors and target sites) are likely to make a significant contribution to phenotypic variation, including disease susceptibility. Here we review basic miRNA biology in animals, survey the available evidence for DNA sequence polymorphisms affecting miRNA-mediated gene regulation and thus phenotype, and discuss their possible importance in the determination of complex traits. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Genetics & Development Elsevier

Polymorphic miRNA-mediated gene regulation: contribution to phenotypic variation and disease

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Publisher
Elsevier
Copyright
Copyright © 2007 Elsevier Ltd
ISSN
0959-437x
D.O.I.
10.1016/j.gde.2007.04.005
Publisher site
See Article on Publisher Site

Abstract

The expression of at least a third of mammalian genes is post-transcriptionally fine-tuned by ∼1000 microRNAs (miRNAs), assisted by the RNA silencing machinery, comprising tens of components. Polymorphisms and mutations in the corresponding sequence space (machinery, miRNA precursors and target sites) are likely to make a significant contribution to phenotypic variation, including disease susceptibility. Here we review basic miRNA biology in animals, survey the available evidence for DNA sequence polymorphisms affecting miRNA-mediated gene regulation and thus phenotype, and discuss their possible importance in the determination of complex traits.

Journal

Current Opinion in Genetics & DevelopmentElsevier

Published: Jun 1, 2007

References

  • Influence of human genome polymorphism on gene expression
    Pastinen, T.; Ge, B.; Hudson, T.J.
  • Genomics of microRNA
    Kim, V.N.; Nam, J.W.
  • Processing of intronic microRNAs
    Kim, Y.K.; Kim, V.N.
  • Post-transcriptional gene silencing by siRNAs and miRNAs
    Filipowicz, W.; Jaskiewicz, L.; Kolb, F.A.; Pillai, R.S.
  • Molecular cloning and expression analysis of a novel gene DGCR8 located in the DiGeorge syndrome chromosomal region
    Shiohama, A.; Sasaki, T.; Noda, S.; Minoshima, S.; Shimizu, N.
  • Polymorphisms in human pre-miRNAs
    Iwai, N.; Naraba, H.
  • Ectopic expression of DLK1 protein in skeletal muscle of padumnal heterozygotes causes the callipyge phenotype
    Davis, E.; Jensen, C.H.; Schroder, H.D.; Farnir, F.; Shay-Hadfield, T.; Kliem, A.; Cockett, N.; Georges, M.; Charlier, C.

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