Molecular Immunology 99 (2018) 182–190 Contents lists available at ScienceDirect Molecular Immunology journal homepage: www.elsevier.com/locate/molimm Polyglutamine binding protein 1 (PQBP1) inhibits innate immune responses to cytosolic DNA Jessica L. Shannon, Molly S. Murphy, Uma Kantheti, Jordan M. Burnett, Marina G. Hahn, Tyler J. Dorrity, Constantinos J. Bacas, Ethan B. Mattice, Kathryna D. Corpuz, Brianne R. Barker Department of Biology, Drew University, 36 Madison Avenue, Madison, NJ 07940, United States ARTIC L E I NF O ABSTRAC T Keywords: Recent studies have highlighted the importance of immune sensing of cytosolic DNA of both pathogen and host DNA sensing origin. We aimed to examine the role of DNA sensors interferon-γ-inducible protein 16 (IFI16) and cyclic GMP- PQBP1 AMP synthase (cGAS) in responding to cytosolic DNA. We show IFI16 and cGAS can synergistically induce IFNb cGAS transcriptional activity in response to cytoplasmic DNA. We also examined the role of polyglutamine binding IFI16 protein 1 (PQBP1), a protein predominantly expressed in lymphoid and myeloid cells that has been shown to pattern recognition receptor lead to type I interferon production in response to retroviral infection. We show PQBP1 associates with cGAS and interferon beta IFI16 in THP-1 cells. Unexpectedly, knockout of PQBP1 in THP-1
Molecular Immunology – Elsevier
Published: Jul 1, 2018
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