Polyglutamine binding protein 1 (PQBP1) inhibits innate immune responses to cytosolic DNA

Polyglutamine binding protein 1 (PQBP1) inhibits innate immune responses to cytosolic DNA Molecular Immunology 99 (2018) 182–190 Contents lists available at ScienceDirect Molecular Immunology journal homepage: www.elsevier.com/locate/molimm Polyglutamine binding protein 1 (PQBP1) inhibits innate immune responses to cytosolic DNA Jessica L. Shannon, Molly S. Murphy, Uma Kantheti, Jordan M. Burnett, Marina G. Hahn, Tyler J. Dorrity, Constantinos J. Bacas, Ethan B. Mattice, Kathryna D. Corpuz, Brianne R. Barker Department of Biology, Drew University, 36 Madison Avenue, Madison, NJ 07940, United States ARTIC L E I NF O ABSTRAC T Keywords: Recent studies have highlighted the importance of immune sensing of cytosolic DNA of both pathogen and host DNA sensing origin. We aimed to examine the role of DNA sensors interferon-γ-inducible protein 16 (IFI16) and cyclic GMP- PQBP1 AMP synthase (cGAS) in responding to cytosolic DNA. We show IFI16 and cGAS can synergistically induce IFNb cGAS transcriptional activity in response to cytoplasmic DNA. We also examined the role of polyglutamine binding IFI16 protein 1 (PQBP1), a protein predominantly expressed in lymphoid and myeloid cells that has been shown to pattern recognition receptor lead to type I interferon production in response to retroviral infection. We show PQBP1 associates with cGAS and interferon beta IFI16 in THP-1 cells. Unexpectedly, knockout of PQBP1 in THP-1 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Immunology Elsevier

Loading next page...
 
/lp/elsevier/polyglutamine-binding-protein-1-pqbp1-inhibits-innate-immune-responses-83nS0Kg0H3
Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0161-5890
D.O.I.
10.1016/j.molimm.2018.05.014
Publisher site
See Article on Publisher Site

Abstract

Molecular Immunology 99 (2018) 182–190 Contents lists available at ScienceDirect Molecular Immunology journal homepage: www.elsevier.com/locate/molimm Polyglutamine binding protein 1 (PQBP1) inhibits innate immune responses to cytosolic DNA Jessica L. Shannon, Molly S. Murphy, Uma Kantheti, Jordan M. Burnett, Marina G. Hahn, Tyler J. Dorrity, Constantinos J. Bacas, Ethan B. Mattice, Kathryna D. Corpuz, Brianne R. Barker Department of Biology, Drew University, 36 Madison Avenue, Madison, NJ 07940, United States ARTIC L E I NF O ABSTRAC T Keywords: Recent studies have highlighted the importance of immune sensing of cytosolic DNA of both pathogen and host DNA sensing origin. We aimed to examine the role of DNA sensors interferon-γ-inducible protein 16 (IFI16) and cyclic GMP- PQBP1 AMP synthase (cGAS) in responding to cytosolic DNA. We show IFI16 and cGAS can synergistically induce IFNb cGAS transcriptional activity in response to cytoplasmic DNA. We also examined the role of polyglutamine binding IFI16 protein 1 (PQBP1), a protein predominantly expressed in lymphoid and myeloid cells that has been shown to pattern recognition receptor lead to type I interferon production in response to retroviral infection. We show PQBP1 associates with cGAS and interferon beta IFI16 in THP-1 cells. Unexpectedly, knockout of PQBP1 in THP-1

Journal

Molecular ImmunologyElsevier

Published: Jul 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off