Platelet surface P-selectin measurements in platelet preparations: An international collaborative study

Platelet surface P-selectin measurements in platelet preparations: An international collaborative... Larry J,. Dumont, Tania VandenBroeke, Kenneth. A. Ault, and the members of the Biomedical Excellence for Safer Transfusion (BEST) Working Party of the International Society of Blood Transfusion (ISBT) HEN developing or evaluating new technology for the preparation, processing, and storage of platelets, it is important to be able to use a panel of in vitro assays that provide information about various platelet properties. This reflects the fact that it is not possible to use routinely in vivo assays, such as radiolabeled platelet recoveries or template bleeding times; for a variety of reasons, including cost and human use issues. It is desirable also to develop in vitro assays that may be useful in monitoring a patient's clinical status for various cardiovascular conditions (eg, acute coronary arterysyndromes, stroke, angioplasty, and preeclampsia). One such potential in vitro measurement, which has received considerable attention, is the expression of P-selectin on platelets. 1,2 P-selectin (also known as CD62R GMP-140, PADGEM) is an integral membrane glycoprotein of the platelet alpha granule and Weibel-Palade body of the endothelial celI. 3,4 It is an important adhesive protein involved in plateIet/leukocyte/endothelial interactions involving leukocyte attachment, rolling, extravasation, and regulation of cytokine synthesis in the leukocyte. 58 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Transfusion Medicine Reviews Elsevier

Platelet surface P-selectin measurements in platelet preparations: An international collaborative study

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Publisher
Elsevier
Copyright
Copyright © 1999 W.B. Saunders Company. All rights reserved
ISSN
0887-7963
D.O.I.
10.1016/S0887-7963(99)80086-8
Publisher site
See Article on Publisher Site

Abstract

Larry J,. Dumont, Tania VandenBroeke, Kenneth. A. Ault, and the members of the Biomedical Excellence for Safer Transfusion (BEST) Working Party of the International Society of Blood Transfusion (ISBT) HEN developing or evaluating new technology for the preparation, processing, and storage of platelets, it is important to be able to use a panel of in vitro assays that provide information about various platelet properties. This reflects the fact that it is not possible to use routinely in vivo assays, such as radiolabeled platelet recoveries or template bleeding times; for a variety of reasons, including cost and human use issues. It is desirable also to develop in vitro assays that may be useful in monitoring a patient's clinical status for various cardiovascular conditions (eg, acute coronary arterysyndromes, stroke, angioplasty, and preeclampsia). One such potential in vitro measurement, which has received considerable attention, is the expression of P-selectin on platelets. 1,2 P-selectin (also known as CD62R GMP-140, PADGEM) is an integral membrane glycoprotein of the platelet alpha granule and Weibel-Palade body of the endothelial celI. 3,4 It is an important adhesive protein involved in plateIet/leukocyte/endothelial interactions involving leukocyte attachment, rolling, extravasation, and regulation of cytokine synthesis in the leukocyte. 58

Journal

Transfusion Medicine ReviewsElsevier

Published: Jan 1, 1999

References

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