Larry J,. Dumont, Tania VandenBroeke, Kenneth. A. Ault, and the members of the Biomedical Excellence for Safer Transfusion (BEST) Working Party of the International Society of Blood Transfusion (ISBT) HEN developing or evaluating new technology for the preparation, processing, and storage of platelets, it is important to be able to use a panel of in vitro assays that provide information about various platelet properties. This reflects the fact that it is not possible to use routinely in vivo assays, such as radiolabeled platelet recoveries or template bleeding times; for a variety of reasons, including cost and human use issues. It is desirable also to develop in vitro assays that may be useful in monitoring a patient's clinical status for various cardiovascular conditions (eg, acute coronary arterysyndromes, stroke, angioplasty, and preeclampsia). One such potential in vitro measurement, which has received considerable attention, is the expression of P-selectin on platelets. 1,2 P-selectin (also known as CD62R GMP-140, PADGEM) is an integral membrane glycoprotein of the platelet alpha granule and Weibel-Palade body of the endothelial celI. 3,4 It is an important adhesive protein involved in plateIet/leukocyte/endothelial interactions involving leukocyte attachment, rolling, extravasation, and regulation of cytokine synthesis in the leukocyte. 58
Transfusion Medicine Reviews – Elsevier
Published: Jan 1, 1999
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