Plant cytosine-5 DNA methyltransferases: Structure, function, and molecular evolution

Plant cytosine-5 DNA methyltransferases: Structure, function, and molecular evolution A detailed analysis of the structure and function, along with evolutionary aspects, of the main plant cytosine-5 DNA methyltransferases (C5-MTases) is presented. The evolutionary relationships between the already known and four candidate plant C5-MTases identified in this work were investigated using the distance, maximum-parsimony, and maximum-likelihood approaches. The topologies of the trees were overall congruent: four monophyletic groups corresponding to the four plant C5-MTase families were clearly distinguished. In addition, sequence analyses of the plant C5-MTase target recognition domain sequences were performed and phylogenetic trees were reconstructed showing that there is good conservation among but not within the plant C5-MTase families. Furthermore, a conserved dipeptide that plays an important role in flipping the target base into the catalytic site of the C5-MTases was identified in all plant C5-MTases under study. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genomics Elsevier

Plant cytosine-5 DNA methyltransferases: Structure, function, and molecular evolution

Genomics, Volume 90 (4) – Oct 1, 2007

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Publisher
Elsevier
Copyright
Copyright © 2007 Elsevier Inc.
ISSN
0888-7543
eISSN
1089-8646
DOI
10.1016/j.ygeno.2007.06.011
Publisher site
See Article on Publisher Site

Abstract

A detailed analysis of the structure and function, along with evolutionary aspects, of the main plant cytosine-5 DNA methyltransferases (C5-MTases) is presented. The evolutionary relationships between the already known and four candidate plant C5-MTases identified in this work were investigated using the distance, maximum-parsimony, and maximum-likelihood approaches. The topologies of the trees were overall congruent: four monophyletic groups corresponding to the four plant C5-MTase families were clearly distinguished. In addition, sequence analyses of the plant C5-MTase target recognition domain sequences were performed and phylogenetic trees were reconstructed showing that there is good conservation among but not within the plant C5-MTase families. Furthermore, a conserved dipeptide that plays an important role in flipping the target base into the catalytic site of the C5-MTases was identified in all plant C5-MTases under study.

Journal

GenomicsElsevier

Published: Oct 1, 2007

References

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