Placebo forte: Ways to maximize unspecific treatment effects

Placebo forte: Ways to maximize unspecific treatment effects Placebo effects spark more and more interest in both medicine and psychotherapy. Neurobiological findings have helped to understand underlying biochemical and neurological mechanisms although many questions remain to be answered. One common denominator of empirical findings regarding placebo effects across a wide range of clinical conditions (e.g., depression, Parkinson’s disease, pain, neurological disorders) is the involvement of higher cognitive brain functions associated with the prefrontal cortex. It is meanwhile commonly accepted that placebo effects involve self-regulatory mechanisms whose role in mediating those effects have not been thoroughly investigated yet. We propose a theoretical framework which helps to identify relevant functional mechanisms. Drawing on psychological findings, we propose a mechanism by which placebo effects can be maximized in any type of medical and psychotherapeutic setting. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Medical Hypotheses Elsevier

Placebo forte: Ways to maximize unspecific treatment effects

Medical Hypotheses, Volume 78 (6) – Jun 1, 2012

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Publisher
Elsevier
Copyright
Copyright © 2012 Elsevier Ltd
ISSN
0306-9877
eISSN
1532-2777
D.O.I.
10.1016/j.mehy.2012.02.022
Publisher site
See Article on Publisher Site

Abstract

Placebo effects spark more and more interest in both medicine and psychotherapy. Neurobiological findings have helped to understand underlying biochemical and neurological mechanisms although many questions remain to be answered. One common denominator of empirical findings regarding placebo effects across a wide range of clinical conditions (e.g., depression, Parkinson’s disease, pain, neurological disorders) is the involvement of higher cognitive brain functions associated with the prefrontal cortex. It is meanwhile commonly accepted that placebo effects involve self-regulatory mechanisms whose role in mediating those effects have not been thoroughly investigated yet. We propose a theoretical framework which helps to identify relevant functional mechanisms. Drawing on psychological findings, we propose a mechanism by which placebo effects can be maximized in any type of medical and psychotherapeutic setting.

Journal

Medical HypothesesElsevier

Published: Jun 1, 2012

References

  • Correlates of placebo response in the treatment of sexual dysfunction in women: a preliminary report
    Bradford, A.; Meston, C.
  • Expectation of caffeine induces dopaminergic responses in humans
    Kaasinen, V.; Aalto, S.; Nagren, K.; Rinne, J.O.
  • Finasteride 5 mg and sexual side effects: how many of these are related to the nocebo phenomenon?
    Mondaini, N.; Gontero, P.; Giubilei, G.
  • Does the presence of a pharmacological substance alter the placebo effect? Results of two experimental studies using the placebo-caffeine paradigm
    Walach, H.; Schneider, R.
  • Self-referential processing in our brain–a meta-analysis of imaging studies on the self
    Northoff, G.; Heinzel, A.; de Greck, M.; Bermpohl, F.; Dobrowolny, H.; Panksepp, J.
  • Placebo effects in laser-evoked pain potentials
    Wager, T.D.; Matre, D.; Casey, K.L.
  • The social neuroscience of empathy
    Singer, T.; Lamm, C.
  • The molecular basis of skeletal muscle atrophy
    Jackman, R.W.; Kandarian, S.C.

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