We report the characterization of a new class of glutamate uptake inhibitors isolated from Phoneutria nigriventer venom. Glutamate transport activity was assayed in rat cerebrocortical synaptosomes by using ( 3 H )- l -glutamate. PhTx4 inhibited glutamate uptake in a dose dependent manner. The IC 50 value obtained was 2.35±0.9 μg/ml which is in the observed range reported for glutamate uptake blockers. Tx4-7, one of PhTx4 toxins, showed the strongest inhibitory activity (50.3±0.69%, n =3).
Brain Research – Elsevier
Published: Jun 12, 1999
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