Photoredox-catalyzed hydroxyfluoroalkylation of alkene with simple fluoroalkyl iodides

Photoredox-catalyzed hydroxyfluoroalkylation of alkene with simple fluoroalkyl iodides Journal of Photochemistry and Photobiology A: Chemistry 355 (2018) 194–201 Contents lists available at ScienceDirect Journal of Photochemistry and Photobiology A: Chemistry journal home page : www.elsevier.com/locat e/jphotochem Invited paper Photoredox-catalyzed hydroxyfluoroalkylation of alkene with simple fluoroalkyl iodides a a a a,b, Xiaoyu Geng , Fengguirong Lin , Xiaoyang Wang , Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing, 100191, China Shanghai Key Laboratory of Green Chemistry and Chemical Processes, East China Normal University, Shanghai, 200062, China A R T I C L E I N F O A B S T R A C T Article history: Hydroxyfluoroalkylation of simple alkenes is presented with readily available fluoroalkyl iodides by the Received 16 July 2017 Received in revised form 30 August 2017 virtue of photoredox catalysis in good efficiency and regioselectivity. This chemistry features mild Accepted 11 September 2017 condition, simple operation and good substrate scope. A variety of styrenes as well as non-activated Available online 18 September 2017 aliphatic alkenes can be selectively transformed to b-fluoroalkylated alcohols. Preliminary mechanistic studies indicated a radical process with fluoroalkyl radicals which were generated from reductive This paper is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Photochemistry and Photobiology A: Chemistry Elsevier

Photoredox-catalyzed hydroxyfluoroalkylation of alkene with simple fluoroalkyl iodides

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier B.V.
ISSN
1010-6030
eISSN
1873-2666
D.O.I.
10.1016/j.jphotochem.2017.09.031
Publisher site
See Article on Publisher Site

Abstract

Journal of Photochemistry and Photobiology A: Chemistry 355 (2018) 194–201 Contents lists available at ScienceDirect Journal of Photochemistry and Photobiology A: Chemistry journal home page : www.elsevier.com/locat e/jphotochem Invited paper Photoredox-catalyzed hydroxyfluoroalkylation of alkene with simple fluoroalkyl iodides a a a a,b, Xiaoyu Geng , Fengguirong Lin , Xiaoyang Wang , Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing, 100191, China Shanghai Key Laboratory of Green Chemistry and Chemical Processes, East China Normal University, Shanghai, 200062, China A R T I C L E I N F O A B S T R A C T Article history: Hydroxyfluoroalkylation of simple alkenes is presented with readily available fluoroalkyl iodides by the Received 16 July 2017 Received in revised form 30 August 2017 virtue of photoredox catalysis in good efficiency and regioselectivity. This chemistry features mild Accepted 11 September 2017 condition, simple operation and good substrate scope. A variety of styrenes as well as non-activated Available online 18 September 2017 aliphatic alkenes can be selectively transformed to b-fluoroalkylated alcohols. Preliminary mechanistic studies indicated a radical process with fluoroalkyl radicals which were generated from reductive This paper is

Journal

Journal of Photochemistry and Photobiology A: ChemistryElsevier

Published: Mar 15, 2018

References

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