Acta Biomaterialia 71 (2018) 460–473 Contents lists available at ScienceDirect Acta Biomaterialia journal homepage: www.elsevier.com/locate/actabiomat Full length article Photooxidatively crosslinked acellular tumor extracellular matrices as potential tumor engineering scaffolds a,⇑,1 b,1 c,⇑ d c a a Wei-Dong Lü , Rui-Fang Sun , Ye-Rong Hu , Jan-Rong Lu ,LuGu , Zhi-Gang Liu , Guang-Yan Lei , a d Zhun Qiang , Lin Cai Department of Thoracic Surgery, Tumor Hospital of Shaanxi Province, Afﬁliated to the Medical College of Xi’an Jiaotong University, Xi’an 710061, Shaanxi, China Department of Pathology, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an 710061, Shaanxi, China Department of Cardiovascular Surgery, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China Department of Pathology, Tumor Hospital of Shaanxi Province, Afﬁliated to the Medical College of Xi’an Jiaotong University, Xi’an 710061, Shaanxi, China ar ti c l e i nf o ab stra ct Article history: Acellular tumor extracellular matrices (ECMs) have limitations when employed as three-dimensional Received 7 November 2017 (3D) scaffolds for tumor engineering. In this work, methylene blue-mediated photooxidation was used Received in revised form 8 February 2018 to crosslink acellular tumor ECMs. Photooxidative crosslinking greatly increased the stiffness of acellular Accepted 8
Acta Biomaterialia – Elsevier
Published: Apr 15, 2018
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